Mittal K
New York University Medical Center and Kaplan Cancer Center, New York 10016, USA.
Int J Gynecol Pathol. 1999 Jul;18(3):211-4. doi: 10.1097/00004347-199907000-00004.
Interpretation of cervical cone biopsy margins removed by loop electrosurgical excision procedure is often problematic as a result of cautery artifacts. In this study, MIB-1 expression in cauterized tissues was almost identical to that in the adjacent noncauterized epithelium (correlation coefficients 0.97-0.98). Cauterized dysplastic/condylomatous epithelium showed significantly greater expression of MIB-1 than cauterized normal epithelium (p < or = 0.004) at all levels of the epithelium. Cut-off points for distinguishing dysplastic/condylomatous epithelium from normal epithelium were >15%, 30%, 5%, and 1% of cells in the basal, basal one-third, middle one-third, and surface one-third of epithelium, respectively.
由于电灼伪像，对通过环形电外科切除程序切除的宫颈锥切活检边缘进行解读往往存在问题。在本研究中，电灼组织中的MIB-1表达与相邻未电灼上皮中的表达几乎相同（相关系数为0.97 - 0.98）。在所有上皮水平，电灼的发育异常/湿疣样上皮显示出比电灼的正常上皮显著更高的MIB-1表达（p≤0.004）。区分发育异常/湿疣样上皮与正常上皮的截断点分别为上皮基底、基底三分之一、中间三分之一和表面三分之一中细胞的>15%、30%、5%和1%。
