Goebel K M, Schneider J, Neitzert A, Richter H, Maroske D
Schweiz Med Wochenschr. 1975 Nov 22;105(47):1578-80.
In patients with shock the metabolic activity of the red blood cells was studied following separation according to cell-age by density layer centrifugation using Stractan II-Urografin solutions. Metabolic acidosis in patients with cardiogenic shock (n = 8) and with postoperative shock (n = 7) induced a pronounced fall in 2,3-diphosphoglycerate (2,3-DPG) levels and in adenosine triphosphate (ATP), in contrast to a raised lactate-pyruvate ratio. 2,3-DPG values were higher than normal in patients with hypoglycemic shock (n = 12), whereas further measured substrate levels were markedly decreased. The levels of these compounds of the red blood cells revealed a significant difference in the hemolysates derived from cells separated according to cell-age. The shock syndrome was also observed in patients suffering from severe congestive heart failure (n = 10) who received dopamine (300 mug/min) for its known action in improving hemodynamics and renal function. Following drug administration for 150 min a clinical improvement was associated with a change of extent and pattern of the red blood cell metabolic disorder.
采用斯特拉坦II - 泛影葡胺溶液，通过密度梯度离心法按细胞年龄分离后，研究了休克患者红细胞的代谢活性。与乳酸 - 丙酮酸比值升高相反，心源性休克患者（n = 8）和术后休克患者（n = 7）的代谢性酸中毒导致2,3 - 二磷酸甘油酸（2,3 - DPG）水平和三磷酸腺苷（ATP）显著下降。低血糖休克患者（n = 12）的2,3 - DPG值高于正常，而进一步测量的底物水平则明显降低。红细胞这些化合物的水平在按细胞年龄分离得到的细胞的溶血产物中显示出显著差异。在患有严重充血性心力衰竭（n = 10）且因多巴胺在改善血流动力学和肾功能方面的已知作用而接受多巴胺（300微克/分钟）治疗的患者中也观察到了休克综合征。给药150分钟后，临床改善与红细胞代谢紊乱的程度和模式变化相关。
