Goebel K M, Goebel F D, Hausmann L
Schweiz Med Wochenschr. 1981 Oct 10;111(41):1538-9.
Red blood cell (RBC) rheological and metabolic functions were studied in 10 diabetics with peripheral vascular disease (PAD) following separation of RBC according to cell age by density layer centrifugation. Decreased levels of ADP, ATP, 2,3-DPG and GSH were observed in dense layers of RBC containing older cell fractions. Further, raised lactate/pyruvate ratios were obtained from the same RBC fractions. O2-function was markedly impaired in all patients with PAD. Thus, metabolic disorder of RBC associated with reduced red cell deformity by retarding blood flow through the microcirculation may be important factors in states of peripheral vascular insufficiency in diabetics.
在通过密度梯度离心法按细胞年龄分离红细胞后，对10例患有外周血管疾病（PAD）的糖尿病患者的红细胞流变学和代谢功能进行了研究。在含有较老细胞组分的红细胞致密层中观察到ADP、ATP、2,3 - DPG和GSH水平降低。此外，从相同的红细胞组分中获得了升高的乳酸/丙酮酸比值。所有PAD患者的氧功能均明显受损。因此，红细胞代谢紊乱与红细胞变形性降低相关，通过阻碍血液在微循环中的流动，可能是糖尿病患者外周血管功能不全状态的重要因素。
