Akehurst Ron L, Brazier John E, Mathers Nigel, O'Keefe Caroline, Kaltenthaler Eva, Morgan Anne, Platts Maria, Walters Stephen J
School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, Sheffield S1 4DA, United Kingdom.
Pharmacoeconomics. 2002;20(7):455-62. doi: 10.2165/00019053-200220070-00003.
To identify the impact of irritable bowel syndrome (IBS) on health-related quality of life (HR-QOL), time off work and the utilisation and cost of health services.
A case-control study was undertaken matching patients with IBS and controls. Quality-of-life information was collected using the Medical Outcomes Study 36-item Short Form (SF-36) health survey, EuroQOL instrument (EQ-5D) and IBS Quality-of-Life (IBS-QOL) instruments. Data on time off work was also collected. National Health Service (NHS) resource use in primary and secondary care was estimated by review of general practitioner (GP) and hospital records over a 12-month period.
Recruitment was from six GPs' surgeries in the Trent Region of the United Kingdom.
161 patients with IBS, as defined by the Rome Criteria I were recruited. These were compared with 213 controls matched for age, sex and social characteristics.
SF-36 and EQ-5D scores; mean number of days off work; mean NHS costs per person during the 12-month study period.
Patients with IBS had considerably lower HR-QOL than controls. They scored worse in all dimensions of the SF-36 and the EQ-5D and they had more time off work. On average patients with IBS cost the NHS 123 UK pounds (95% confidence interval: 35 UK pounds to 221 UK pounds, 1999 values) more per year than individuals in the control group (p = 0.04).
IBS affects patients through reduced quality of life, more time off work and greater healthcare utilisation than a control group of patients without IBS. The difference in quality of life was pronounced and unusual in that it was influential in every dimension of both the SF-36 and the EQ-5D.
确定肠易激综合征（IBS）对健康相关生活质量（HR-QOL）、误工时间以及医疗服务利用和成本的影响。
开展了一项病例对照研究，对IBS患者与对照进行匹配。使用医学结局研究36项简表（SF-36）健康调查、欧洲五维度健康量表（EQ-5D）和肠易激综合征生活质量量表（IBS-QOL）收集生活质量信息。还收集了误工时间数据。通过回顾12个月期间全科医生（GP）和医院记录来估算英国国家医疗服务体系（NHS）在初级和二级医疗保健中的资源使用情况。
招募工作来自英国特伦特地区的六个全科医生诊所。
招募了161名符合罗马标准I定义的IBS患者。将这些患者与213名在年龄、性别和社会特征方面匹配的对照进行比较。
SF-36和EQ-5D评分；平均误工天数；12个月研究期间每人的平均NHS成本。
IBS患者的HR-QOL显著低于对照。他们在SF-36和EQ-5D的所有维度上得分都更低，且误工时间更长。平均而言，IBS患者每年比对照组个体多花费NHS 123英镑（95%置信区间：35英镑至221英镑，199年数值）（p = 0.04）。
与无IBS的对照组患者相比，IBS通过降低生活质量、增加误工时间和更高的医疗服务利用率来影响患者。生活质量的差异很显著且不同寻常，因为它在SF-36和EQ-5D的每个维度上都有影响。
