Focusing on the genetics of hearing: you ain't heard nothin' yet.

Parkinson Nick, Brown Steve D M

MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, OX11 ORD, UK.

Genome Biol. 2002;3(6):COMMENT2006. doi: 10.1186/gb-2002-3-6-comment2006. Epub 2002 May 28.

The complexity of genetic pathways for hearing is beginning to be amenable to unraveling by systematic functional genomic analysis. Genome-wide mutagenesis studies in the mouse are beginning to shed further light on the structure and regulation of the machinery of hearing.

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Parkinson Nick, Brown Steve D M

MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, OX11 ORD, UK.

Genome Biol. 2002;3(6):COMMENT2006. doi: 10.1186/gb-2002-3-6-comment2006. Epub 2002 May 28.

相似文献

Focusing on the genetics of hearing: you ain't heard nothin' yet.

Genome Biol. 2002;3(6):COMMENT2006. doi: 10.1186/gb-2002-3-6-comment2006. Epub 2002 May 28.

IDS, 2015: You Ain't Seen Nothin' Yet.

Dent Today. 2015 Apr;34(4):30.

Vision and action: you ain't seen nothin' yet ..

Perception. 1997;26(1):1-6. doi: 10.1068/p260001.

Medicare cost shifting: you ain't seen nothin' yet.

Bus Health. 1990 May;8(5):46, 48-9.

[Molecular biology of hearing].

Laryngorhinootologie. 2011 Mar;90 Suppl 1:S22-34. doi: 10.1055/s-0030-1270444. Epub 2011 Apr 26.

Gene expression profile of the mouse organ of Corti at the onset of hearing.

Genomics. 2004 Jun;83(6):1000-11. doi: 10.1016/j.ygeno.2004.01.005.

Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice.

PLoS One. 2015 Mar 30;10(3):e0120674. doi: 10.1371/journal.pone.0120674. eCollection 2015.

A genetic approach to understanding auditory function.

Nat Genet. 2001 Feb;27(2):143-9. doi: 10.1038/84758.

Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling.

Dev Cell. 2005 Apr;8(4):553-64. doi: 10.1016/j.devcel.2005.02.009.

From deafness genes to hearing mechanisms: harmony and counterpoint.

Trends Mol Med. 2006 Feb;12(2):57-64. doi: 10.1016/j.molmed.2005.12.006. Epub 2006 Jan 10.

引用本文的文献

ClinGen expert clinical validity curation of 164 hearing loss gene-disease pairs.

Genet Med. 2019 Oct;21(10):2239-2247. doi: 10.1038/s41436-019-0487-0. Epub 2019 Mar 21.

Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss.

Genes Brain Behav. 2009 Oct;8(7):699-713. doi: 10.1111/j.1601-183X.2009.00514.x. Epub 2009 Jun 22.

Mouse models for human otitis media.

Brain Res. 2009 Jun 24;1277:90-103. doi: 10.1016/j.brainres.2009.02.047. Epub 2009 Mar 6.

Mouse models as a tool to unravel the genetic basis for human otitis media.

Brain Res. 2006 May 26;1091(1):9-15. doi: 10.1016/j.brainres.2006.01.046.

A quantitative survey of gravity receptor function in mutant mouse strains.

J Assoc Res Otolaryngol. 2005 Dec;6(4):297-310. doi: 10.1007/s10162-005-0009-4.

本文引用的文献

ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis.

Mamm Genome. 2002 Mar;13(3):142-8. doi: 10.1007/BF02684018.

Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.

Nat Genet. 2002 Mar;30(3):257-8. doi: 10.1038/ng848. Epub 2002 Feb 19.

Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function.

Nat Genet. 2002 Mar;30(3):277-84. doi: 10.1038/ng842. Epub 2002 Feb 19.

Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations.

Nat Neurosci. 2002 Jan;5(1):41-7. doi: 10.1038/nn784.

Challenges for the 21st century.

Nat Genet. 2001 Dec;29(4):353-4. doi: 10.1038/ng1201-353.

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

Nat Genet. 2001 Nov;29(3):345-9. doi: 10.1038/ng726.

On the allelic spectrum of human disease.

Trends Genet. 2001 Sep;17(9):502-10. doi: 10.1016/s0168-9525(01)02410-6.

Are rare variants responsible for susceptibility to complex diseases?

Am J Hum Genet. 2001 Jul;69(1):124-37. doi: 10.1086/321272. Epub 2001 Jun 12.

Systematic approaches to mouse mutagenesis.

Curr Opin Genet Dev. 2001 Jun;11(3):268-73. doi: 10.1016/s0959-437x(00)00189-1.

The Notch ligand Jagged1 is required for inner ear sensory development.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3873-8. doi: 10.1073/pnas.071496998. Epub 2001 Mar 20.

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