小鼠模型作为揭示人类中耳炎遗传基础的工具。
Mouse models as a tool to unravel the genetic basis for human otitis media.
作者信息
Zheng Qing Yin, Hardisty-Hughes Rachel, Brown Steve D M
机构信息
Department of Otolaryngology, Case Western Reserve Universuty, Cleveland, OH 44106, USA.
出版信息
Brain Res. 2006 May 26;1091(1):9-15. doi: 10.1016/j.brainres.2006.01.046.
Abstract
The pathogenesis of otitis media (OM) is multifactorial and includes infection, anatomical factors, immunologic status, genetic predisposition, and environmental factors. OM remains the most common cause of hearing impairment in childhood. Genetic predisposition is increasingly recognized as an important factor. The completion of the mouse genome sequence has offered a powerful basket of tools for investigating gene function and can expect to generate a rich resource of mouse mutants for the elucidation of genetic factors underlying OM. We review the literature and discuss recent progresses in developing mouse models and using mouse models to uncover the genetic basis for human OM.
摘要
中耳炎（OM）的发病机制是多因素的，包括感染、解剖因素、免疫状态、遗传易感性和环境因素。中耳炎仍然是儿童听力障碍的最常见原因。遗传易感性日益被认为是一个重要因素。小鼠基因组序列的完成提供了一系列强大的工具来研究基因功能，并有望产生丰富的小鼠突变体资源，以阐明中耳炎潜在的遗传因素。我们回顾了文献，并讨论了在开发小鼠模型以及使用小鼠模型揭示人类中耳炎遗传基础方面的最新进展。
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