非裔美国农民体内的滴滴涕代谢物与雄激素

DDT metabolite and androgens in African-American farmers.

作者信息

Martin Stephen A, Harlow Siobán D, Sowers Mary Fran, Longnecker Matthew P, Garabrant David, Shore David L, Sandler Dale P

机构信息

National Institute of Environmental Health Sciences, Epidemiology Branch, MD A3-05, Research Triangle Park, NC 27709, USA.

出版信息

Epidemiology. 2002 Jul;13(4):454-8. doi: 10.1097/00001648-200207000-00014.

DOI:10.1097/00001648-200207000-00014

PMID:12094101

Abstract

BACKGROUND

The ubiquitous dichlorodiphenyltrichloroethane (DDT) metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) is an androgen receptor antagonist. Data on potential antiandrogenic activity of DDE in humans are limited.

METHODS

The relations between concentrations of plasma DDE and several serum androgens (total testosterone, bioavailable testosterone, 5alpha-dihydrotestosterone, and free androgen index) were examined in 137 North Carolina black male farmers, using multiple linear regression.

RESULTS

Participants ranged in age from 30 to 88 years (mean = 62 years). Most had farmed for about 30 years and 27% reported having used DDT. The median DDE level was 7.7 microg per liter (1213 microg per kg lipid), slightly higher than in other recent studies. Overall, concentrations of DDE and androgens were unrelated. Total testosterone decreased 2% (95% confidence limits [CL] = -9%, 5%) per increase in interquartile distance of lipid-adjusted DDE. The percentage change in other hormones was similarly negligible. However, among those whose DDE level was in the top tenth percentile, compared with all others, total testosterone and free androgen index were lower by 23% (CL= -40%, 1%) and 22% (CL =-41%, 4%) respectively. Plasma androgen levels decreased with age, a relation that has previously been studied only in whites.

CONCLUSIONS

Studies of more highly exposed populations may be needed to evaluate effects, if any, of DDE.

摘要

背景

普遍存在的二氯二苯三氯乙烷（DDT）代谢产物1,1-二氯-2,2-双（对氯苯基）乙烯（DDE）是一种雄激素受体拮抗剂。关于DDE在人类中的潜在抗雄激素活性的数据有限。

方法

采用多元线性回归分析了137名北卡罗来纳州黑人男性农民血浆DDE浓度与几种血清雄激素（总睾酮、生物可利用睾酮、5α-二氢睾酮和游离雄激素指数）之间的关系。

结果

参与者年龄在30至88岁之间（平均62岁）。大多数人从事农业工作约30年，27%的人报告曾使用过DDT。DDE的中位数水平为每升7.7微克（每千克脂质1213微克），略高于近期的其他研究。总体而言，DDE浓度与雄激素无关。脂质调整后的DDE四分位间距每增加1个单位，总睾酮下降2%（95%置信区间[CL]=-9%，5%）。其他激素的变化百分比同样微不足道。然而，在DDE水平处于最高十分位数的人群中，与所有其他人相比，总睾酮和游离雄激素指数分别低23%（CL=-40%，1%）和22%（CL=-41%，4%）。血浆雄激素水平随年龄下降，这种关系此前仅在白人中进行过研究。