de Moura Neusa F, Morel Ademir F, Dessoy Emilia C, Zanatta Nilo, Bürger Marilise M, Ahlert Neusa, Porto Gerusa P, Baldisserotto Bernardo
Departamento de Quimica, Universidade Federal de Santa Maria, RS, Brazil.
Planta Med. 2002 Jun;68(6):534-8. doi: 10.1055/s-2002-32550.
Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolated as new natural products from the stem barks of Zanthoxylum hyemale, together with seven known compounds. Their structures were determined on the basis of spectroscopic data (IR, (1)H- and (13)C-NMR, MS). In addition, the antispasmodic activity of the crude extract of Z. hyemale and three other more abundant isolated compounds (4, 5 and 10) were studied in two different antispasmodic test models on isolated rat ileum and only the crude ethanolic extract presented antispasmodic activity.
从大叶花椒的茎皮中分离出两种喹啉生物碱，(-)-R-盖尔巴兰辛（1）和透明菌素（2），以及芳香酰胺N-[2-(3,4-二甲氧基苯基)-2-甲氧基乙基)-2-甲氧基乙基]苯甲酰胺（O-甲基巴尔斯酰胺）（3）作为新的天然产物，同时还分离出七种已知化合物。它们的结构是根据光谱数据（红外光谱、(1)H-和(13)C-核磁共振、质谱）确定的。此外，在两种不同的离体大鼠回肠解痉试验模型中研究了大叶花椒粗提取物和其他三种含量较高的分离化合物（4、5和10）的解痉活性，只有粗乙醇提取物表现出解痉活性。
