从莪术根茎中分离出的天然倍半萜对前列腺素E2和一氧化氮生成的抑制作用。
Inhibitory effects of natural sesquiterpenoids isolated from the rhizomes of Curcuma zedoaria on prostaglandin E2 and nitric oxide production.
作者信息
Hong Chae Hee, Noh Min Soo, Lee Woo Young, Lee Sang Kook
出版信息
Planta Med. 2002 Jun;68(6):545-7. doi: 10.1055/s-2002-32560.
PMID:12094302
Abstract
Beta-turmerone and ar-turmerone, sesquiterpenoids isolated from the rhizome of Curcuma zedoaria, inhibited lipopolysaccharide (LPS)-induced prostaglandin E 2 production in cultured mouse macrophage cell RAW 264.7 in a dose-dependent manner (IC 50 = 7.3 microM for beta-turmerone; IC 50 = 24.0 microM for ar-turmerone). In addition, these compounds exhibited inhibitory effects on LPS-induced nitric oxide production in the cell system.
摘要
从莪术根茎中分离得到的倍半萜类化合物β-姜黄烯和芳姜黄烯，以剂量依赖的方式抑制脂多糖（LPS）诱导的培养小鼠巨噬细胞RAW 264.7中前列腺素E2的产生（β-姜黄烯的IC50 = 7.3微摩尔；芳姜黄烯的IC50 = 24.0微摩尔）。此外，这些化合物在细胞体系中对LPS诱导的一氧化氮产生也表现出抑制作用。
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