van Maanen C
Animal Health Service, Deventer, The Netherlands.
Vet Q. 2002 Jun;24(2):58-78.
Equine herpesvirus 1 (EHV1) and equine herpesvirus 4 (EHV4) are important ubiquitous equine viral pathogens, causing much damage to the horse industry. EHV1 strains are associated with respiratory disease, abortion, and paresis/paralysis, whereas EHV4 strains are predominantly associated with respiratory disease. In the past decades much research effort has been put into improving knowledge about these viruses. In this paper the current state of knowledge of these viruses and the most important aspects of these virus infections, e.g. epidemiology, clinical aspects, pathogenesis and pathology, immunity, diagnosis, preventive management and management in the course of an outbreak and vaccination, is reviewed. Because we performed some research ourselves in the areas of diagnosis, epidemiology and vaccinology these aspects are reviewed in more depth than the other aspects. Still many questions have remained and new questions have risen. Consequently, research priorities should be made in an attempt to answer these questions. Therefore, this review ends with some personal recommendations for important priorities for future research.
马疱疹病毒1型（EHV1）和马疱疹病毒4型（EHV4）是重要的、广泛存在的马病毒性病原体，给养马业造成了很大损失。EHV1毒株与呼吸道疾病、流产以及轻瘫/麻痹有关，而EHV4毒株主要与呼吸道疾病有关。在过去几十年里，人们投入了大量研究精力来增进对这些病毒的了解。本文综述了这些病毒的现有知识以及这些病毒感染的最重要方面，如流行病学、临床方面、发病机制和病理学、免疫、诊断、预防管理以及疫情期间的管理和疫苗接种。由于我们自己在诊断、流行病学和疫苗学领域开展了一些研究，因此对这些方面的综述比对其他方面的综述更深入。尽管如此，仍然存在许多问题，并且出现了新的问题。因此，应该确定研究重点，试图回答这些问题。因此，本综述最后给出了一些关于未来重要研究重点的个人建议。
