Fulhorst Charles F, Bennett Stephen G, Milazzo Mary L, Murray Hugh L, Webb James P, Cajimat Maria N B, Bradley Robert D
Department of Pathology, University of Texas Medical Branch, Galveston, 77888-0609, USA.
Emerg Infect Dis. 2002 Jul;8(7):717-21. doi: 10.3201/eid0807.010281.
Thirty-four rodents captured in southern California were studied to increase our knowledge of the arenaviruses indigenous to the western United States. An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents. Analyses of viral nucleocapsid protein gene sequence data indicated that the isolates from the California mice are strains of a novel Tacaribe serocomplex virus (proposed name "Bear Canyon") that is phylogenetically most closely related to Whitewater Arroyo and Tamiami viruses, the only other Tacaribe serocomplex viruses known to occur in North America. The discovery of Bear Canyon virus is the first unequivocal evidence that the virus family Arenaviridae is naturally associated with the rodent genus Peromyscus and that a Tacaribe serocomplex virus occurs in California.
为了增进我们对美国西部本土沙粒病毒的了解，研究人员对在南加州捕获的34只啮齿动物进行了研究。从27只加利福尼亚小鼠中的5只身上分离出了一种具有传染性的沙粒病毒，但在其他7只啮齿动物身上均未分离到。对病毒核衣壳蛋白基因序列数据的分析表明，从加利福尼亚小鼠身上分离出的病毒是一种新型塔卡里比血清复合群病毒（提议命名为“熊峡谷病毒”）的毒株，在系统发育上与白水阿罗约病毒和塔米亚米病毒关系最为密切，这两种病毒是已知在北美出现的仅有的其他塔卡里比血清复合群病毒。熊峡谷病毒的发现是第一个明确证据，表明沙粒病毒科与白足鼠属自然相关，且一种塔卡里比血清复合群病毒存在于加利福尼亚州。
