Haebe Jeffrey, Martin James, Tekepety Francis, Tummon Ian, Shepherd Karen
Fertility Centre, Civic Hospital-Parkdale Clinic, The University of Ottawa, Ontario, Ottawa, Canada.
Fertil Steril. 2002 Jul;78(1):29-33. doi: 10.1016/s0015-0282(02)03168-0.
To determine how advancing female age decreases successful outcomes of intrauterine insemination (IUI) alone or combined with ovarian stimulation.
Retrospective review.
Academic fertility center.
PATIENT(S): Infertile men and women.
INTERVENTION(S): Intrauterine insemination alone or combined with ovarian stimulation.
MAIN OUTCOME MEASURE(S): Pregnancy rates, miscarriage rates, and live birth rates per insemination cycle according to female age.
RESULT(S): The 1,117 cycles of IUI resulted in 217 pregnancies, for an overall pregnancy rate for all female ages of 19.4% and a live birth rate of 12.9% per cycle inseminated. The overall live birth rate per insemination declined with advancing maternal age.
CONCLUSION(S): Advancing female age decreases successful outcomes with IUI. The live birth rate with IUI for women 40-42 years old (n = 82) was 9.8% per insemination and may demonstrate that IUI is an appropriate treatment for this age group of women.
确定女性年龄增长如何降低单纯子宫内人工授精（IUI）或联合卵巢刺激的成功受孕率。
回顾性研究。
学术性生育中心。
不孕的男性和女性。
单纯子宫内人工授精或联合卵巢刺激。
根据女性年龄，每个授精周期的妊娠率、流产率和活产率。
1117个IUI周期产生了217次妊娠，所有女性年龄的总体妊娠率为19.4%，每个授精周期的活产率为12.9%。随着母亲年龄的增长，每个授精周期的总体活产率下降。
女性年龄增长会降低IUI的成功受孕率。40 - 42岁女性（n = 82）的IUI活产率为每次授精9.8%，这可能表明IUI是该年龄组女性的一种合适治疗方法。
