Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, ul. Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, ul. Wita Stwosza 59, 80-308 Gdańsk, Poland.
Molecules. 2021 Mar 30;26(7):1934. doi: 10.3390/molecules26071934.
Aging is associated with a drastic decline in fertility/fecundity and with an increased risk of pregnancy complications. Resveratrol (RES), a natural polyphenolic compound, has shown anti-oxidant and anti-inflammatory activities in both human and animal models, thus representing a potential therapeutic and prophylactic anti-aging supplement. Here, we investigated whether preconceptional resveratrol supplementation improved reproductive outcomes in mid-aged (8-month-old) and old (12-month-old) C57BL/6J female mice. Female siblings were cohoused and assigned to either RES or vehicle supplementation to drinking water for 10 consecutive weeks. Subsequently, females were mated with non-supplemented males and their pregnancy outcomes were monitored. RES improved mating success in old, but not in mid-aged females, and prevented the occurrence of delivery complications in the latter. These results indicate that preconceptional RES supplementation could partially improve age-related reproductive complications, but it was not sufficient to restore fecundity in female mice at a very advanced age.
衰老是生育力/生殖力急剧下降和妊娠并发症风险增加的相关因素。白藜芦醇（RES）是一种天然多酚化合物，在人类和动物模型中均表现出抗氧化和抗炎活性，因此是一种潜在的治疗和预防衰老的补充剂。在这里，我们研究了在中年（8 个月大）和老年（12 个月大）C57BL/6J 雌性小鼠中，孕前 RES 补充是否能改善生殖结局。雌性同窝饲养并被分配到 RES 或载体补充物中，连续 10 周添加到饮用水中。随后，雌性与未补充的雄性交配，并监测其妊娠结局。RES 提高了老年雌性的交配成功率，但对中年雌性没有作用，并防止了后者出现分娩并发症。这些结果表明，孕前 RES 补充可以部分改善与年龄相关的生殖并发症，但对于非常高龄的雌性小鼠，恢复生育力还不够。
