Preston Kenzie L, Umbricht Annie, Epstein David H
National Institute on Drug Abuse (NIDA) Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA.
Drug Alcohol Depend. 2002 Jul 1;67(2):125-37. doi: 10.1016/s0376-8716(02)00023-6.
Relapse to drug use is often seen when contingencies designed to reduce drug use are discontinued. This paper reports on a stepdown maintenance contingency and 1-year follow-up in 110 patients who were maintained on methadone (50 or 70 mg/day) and who had completed a contingency management trial targeted to decreasing their opiate use. In the prior study (induction phase, 8 weeks) participants received vouchers for each opiate-negative urine screen or noncontingently.
In this study (maintenance phase, 12 weeks), participants were rerandomized to receive vouchers and take-home methadone doses contingent on providing opiate-negative urine specimens (N=55) or noncontingently (N=55). Since participants had been rerandomized from induction-phase contingencies, most study data were analyzed as if from a 2 x 2 (inductionxmaintenance) design. Follow-up interviews were conducted at 3, 6, and 12 months after study participation.
Patients who received the maintenance contingency following an 8-week induction contingency had better outcomes than those who received noncontingent incentives in either the maintenance or induction phases of the trial. Good outcome at follow-up was predicted by enrollment in methadone maintenance after the study. Significantly more participants in the maintenance contingency group transferred directly to another methadone program.
These findings support the therapeutic value of extending the duration of contingency management and long-term methadone maintenance.
当旨在减少药物使用的应急措施停止时,经常会出现药物使用复发的情况。本文报告了一项逐步减少维持性应急措施及对110名患者进行1年随访的研究,这些患者接受美沙酮维持治疗(50或70毫克/天),并完成了一项旨在减少其阿片类药物使用的应急管理试验。在先前的研究(诱导期,8周)中,参与者每次阿片类药物阴性尿液筛查或非应急情况下均可获得代金券。
在本研究(维持期,12周)中,参与者被重新随机分组,根据提供阿片类药物阴性尿液样本接受代金券和带回家的美沙酮剂量(N = 55)或非应急情况下接受(N = 55)。由于参与者是从诱导期应急措施中重新随机分组的,因此大多数研究数据的分析方式就好像来自2×2(诱导×维持)设计。在参与研究后的3、6和12个月进行随访访谈。
在8周诱导性应急措施后接受维持性应急措施的患者,其结局优于在试验的维持期或诱导期接受非应急激励的患者。研究后参加美沙酮维持治疗可预测随访时的良好结局。维持性应急措施组中直接转至另一个美沙酮项目的参与者明显更多。
这些发现支持了延长应急管理持续时间和长期美沙酮维持治疗的治疗价值。