丁基羟基茴香醚对家兔致畸性的研究。
A study of the teratogenicity of butylated hydroxyanisole on rabbits.
作者信息
Hansen E, Meyer O
出版信息
Toxicology. 1978 Jun;10(2):195-201. doi: 10.1016/0300-483x(78)90069-0.
PMID:684764
Abstract
A teratogenicity study on butylated hydroxyanisole (BHA) was carried out in SPF New Zealand White rabbits. BHA was given by gavage from day 7--18 of the gestation period in doses of 0, 50, 200 and 400 mg/kg body wt./day. The fetuses were removed on day 28. No effect related to the treatment with BHA was observed on the number of corpora luteae, implantations, fetuses dead or alive, or on gross malformations, skeletal and internal malformations, and on the weight of the fetuses.
摘要
对丁基羟基茴香醚（BHA）进行了致畸性研究，实验对象为无特定病原体的新西兰白兔。在妊娠期第7至18天，通过灌胃给予BHA，剂量分别为0、50、200和400毫克/千克体重/天。在第28天取出胎儿。未观察到与BHA处理相关的对黄体数量、着床、死活胎儿数量、大体畸形、骨骼和内部畸形以及胎儿体重的影响。
Zotero 插件