Choi J-I, Chung S-W, Kang H-S, Rhim B Y, Kim S-J, Kim S-J
Department of Periodontology, School of Dentistry, Pusan National University, 1-10 Ami-Dong, Seo-Ku, Pusan 602-739, Korea.
J Dent Res. 2002 May;81(5):344-8. doi: 10.1177/154405910208100511.
Human atherosclerotic plaques contain heat-shock proteins which may serve as potential targets of the immune response in atherosclerosis. Since periodontal infections are suggested as risk factors for the development of cardiovascular diseases, we undertook the present study to evaluate the T-cell immune responses specific to Porphyromonas gingivalis (P. gingivalis) heat-shock protein (hsp)60 in patients suffering from atherosclerosis. Anti-P. gingivalis hsp60 IgG antibody titers were elevated in all patients. We could establish P. gingivalis hsp-specific T-cell lines from the atheroma lesions and the peripheral blood. The T-cell lines were a mixture of CD4+ and CD8+ cells producing the cytokines characteristic of both Th1 and Th2 subsets. The present findings suggest that the T-cell immune response specific to P. gingivalis hsp60 may be involved in the immunopathologic process of atherosclerotic diseases.
人类动脉粥样硬化斑块含有热休克蛋白，这些蛋白可能是动脉粥样硬化免疫反应的潜在靶点。由于牙周感染被认为是心血管疾病发生的危险因素，我们开展了本研究，以评估动脉粥样硬化患者中针对牙龈卟啉单胞菌（P. gingivalis）热休克蛋白（hsp）60的T细胞免疫反应。所有患者中抗牙龈卟啉单胞菌hsp60 IgG抗体滴度均升高。我们能够从动脉粥样硬化病变和外周血中建立牙龈卟啉单胞菌hsp特异性T细胞系。这些T细胞系是CD4+和CD8+细胞的混合物，产生Th1和Th2亚群特有的细胞因子。目前的研究结果表明，针对牙龈卟啉单胞菌hsp60的T细胞免疫反应可能参与了动脉粥样硬化疾病的免疫病理过程。
