Tso M O, La Piana F G
Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1975 Nov-Dec;79(6):OP788-95.
Three patients who had malignant melanomas of the uvea and normal foveas agreed to look at the sun for one hour before enucleation of the eyes. Two of the patients sungazed with an undilated pupil, and 24 hours later, recovered their preexposure visual acuity with no detectable scotoma. One of the patients looked at the sun with a partially dilated pupil, and 24 hours later her visual acuity dropped from 20/20 to 20/25. After sungazing, all three eyes exhibited a prolonged recovery time from the photostress test. Fluorescein angiography in two patients showed that there was leakage of dye in the fovea. Fluorescein angiography done two days earlier had revealed no abnormalities. The foveas of all patients were studied by light and electron microscopy. Two patients showed sloughing of necrotic RPE into the subretinal space at the fovea. Degenerative changes and loss of melanin granules were obsered in the RPE in the fovea of the third patient. This study shows that in spite of the minimal subjective visual impairment, leakage of fluorescein from the choroidal vasculature and histologic changes in the fovea could be demonstrated after exposure to the sunlight.
三名患有葡萄膜恶性黑色素瘤且中央凹正常的患者同意在眼球摘除术前直视太阳一小时。其中两名患者在瞳孔未散大的情况下直视太阳，24小时后，恢复了暴露前的视力，且未检测到暗点。其中一名患者在瞳孔部分散大的情况下直视太阳，24小时后其视力从20/20降至20/25。直视太阳后，所有三只眼睛的光应激试验恢复时间都延长了。两名患者的荧光素血管造影显示中央凹有染料渗漏。两天前进行的荧光素血管造影未发现异常。对所有患者的中央凹进行了光镜和电镜研究。两名患者的中央凹处可见坏死的视网膜色素上皮（RPE）脱落至视网膜下间隙。在第三名患者的中央凹RPE中观察到了退行性改变和黑色素颗粒丢失。这项研究表明，尽管主观视力损害极小，但暴露于阳光后仍可证明脉络膜血管系统有荧光素渗漏以及中央凹有组织学改变。
