在温和条件下，使用1,4-双膦配体通过铑（I）催化（E）-和（Z）-β-（酰氨基）丙烯酸酯的对映选择性氢化反应。
Rh(I)-catalyzed enantioselective hydrogenation of (E)- and (Z)-beta-(acylamino)acrylates using 1,4-bisphosphine ligands under mild conditions.
作者信息
Lee Sang-gi, Zhang Yong Jian
机构信息
Life Sciences Division, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea.
出版信息
Org Lett. 2002 Jul 11;4(14):2429-31. doi: 10.1021/ol0261884.
[reaction: see text] Rh-Me-BDPMI (1a) complex can be an effective catalyst for the hydrogenations of (E)- and (Z)-beta-(acylamino)acrylates, in which the Z-isomers hydrogenated with the same or even higher ee values than the corresponding E-isomers. The conversion yield and enantioselectivity of E- and Z-isomers were largely dependent on the solvent, and thus, the E-isomers were hydrogenated more effectively in CH(2)Cl(2), whereas the Z-isomers were hydrogenated more effectively in polar MeOH solvent.
[反应：见正文]Rh-Me-BDPMI（1a）配合物可以成为（E）-和（Z）-β-（酰氨基）丙烯酸酯氢化反应的有效催化剂，其中Z异构体氢化时的对映体过量值与相应的E异构体相同甚至更高。E异构体和Z异构体的转化率和对映选择性在很大程度上取决于溶剂，因此，E异构体在CH₂Cl₂中氢化更有效，而Z异构体在极性MeOH溶剂中氢化更有效。
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