富电子P-手性二膦的Rh(i)配合物催化(E)-β-(酰基氨基)丙烯酸酯的高度对映选择性氢化反应。
Highly enantioselective hydrogenation of (E)-beta-(acylamino)acrylates catalyzed by Rh(i)-complexes of electron-rich P-chirogenic diphosphines.
作者信息
Yasutake M, Gridnev I D, Higashi N, Imamoto T
机构信息
Department of Chemistry, Faculty of Science, Chiba University, Chiba 263-8522, Japan.
出版信息
Org Lett. 2001 May 31;3(11):1701-4. doi: 10.1021/ol0158967.
PMID:11405690
Abstract
Excellent enantioselectivities up to 99.7% were achieved in the hydrogenation of (E)-beta-(acylamino)acrylates by the use of Rh(I)-complexes of electron-rich diphosphines, t-Bu-BisP and t-Bu-MiniPHOS. Low-temperature NMR experiments testify that monohydrides with beta-carbon atom of the substrate bound to rhodium are involved in the catalytic cycle.
摘要
通过使用富电子二膦的铑（I）配合物t-Bu-BisP和t-Bu-MiniPHOS，在（E）-β-（酰氨基）丙烯酸酯的氢化反应中实现了高达99.7%的优异对映选择性。低温核磁共振实验证明，底物的β-碳原子与铑结合的单氢化物参与了催化循环。
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