先兆子痫女性肿瘤坏死因子-α基因的多态性
Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia.
作者信息
Heiskanen Jaana, Romppanen Eeva-Liisa, Hiltunen Mikko, Iivonen Susan, Mannermaa Arto, Punnonen Kari, Heinonen Seppo
机构信息
Department of Obstetrics and Gynecology, Kuopio University Hospital, Finland.
出版信息
J Assist Reprod Genet. 2002 May;19(5):220-3. doi: 10.1023/a:1015306818507.
PURPOSE
We determined whether genetic variability in the gene encoding for tumor necrosis factor-alpha (TNF-alpha) contributes to individual differences in susceptibility to the development of preeclampsia.
METHODS
The study involved 133 preeclamptic and 115 healthy control pregnant women who were genotyped for C-850T polymorphism in the TNF-alpha gene promoter. Chi-square analysis was used to assess genotype and allele frequency differences between preeclamptic women and controls.
RESULTS
A significantly different genotype distribution of C-850T polymorphism was observed between the two groups, with the frequency of the variant T allele being significantly reduced in the preeclamptic group (4.5%) when compared with the control group (9.6%) (P = 0.03; OR = 0.45, 95% CI = 0.22-0.92). Accordingly, the odds ratio for preeclampsia associated with the pooled TT and CT genotypes was 0.367 (P = 0.02; 95% CI = 0.159-0.847).
CONCLUSIONS
The T allele of the TNF-alpha gene may modify individual preeclampsia risk, being protective against the development of the complication.
目的
我们确定编码肿瘤坏死因子-α（TNF-α）的基因中的遗传变异性是否会导致个体患先兆子痫易感性的差异。
方法
该研究纳入了133例先兆子痫孕妇和115例健康对照孕妇，对她们进行了TNF-α基因启动子中C-850T多态性的基因分型。采用卡方分析评估先兆子痫孕妇与对照组之间的基因型和等位基因频率差异。
结果
两组间C-850T多态性的基因型分布存在显著差异，与对照组（9.6%）相比，先兆子痫组中变异T等位基因的频率显著降低（4.5%）（P = 0.03；OR = 0.45，95% CI = 0.22 - 0.92）。因此，与合并的TT和CT基因型相关的先兆子痫的比值比为0.367（P = 0.02；95% CI = 0.159 - 0.847）。
结论
TNF-α基因的T等位基因可能会改变个体患先兆子痫的风险，对该并发症的发生具有保护作用。
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