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静脉注射替罗非班进行椎基底动脉溶栓：病例报告

Vertebrobasilar thrombolysis with intravenous tirofiban: case report.

作者信息

Liebeskind David S, Pollard John R, Schwartz Eric D, Cucchiara Brett L, McGarvey Michael L, Hurst Robert W

机构信息

Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

出版信息

J Thromb Thrombolysis. 2002 Apr;13(2):81-4. doi: 10.1023/a:1016242713327.

DOI:10.1023/a:1016242713327
PMID:12101384
Abstract

The use of thrombolytic agents in the setting of established cerebral infarction is limited by concerns for hemorrhagic transformation. Novel thrombolytic approaches, which have received minimal consideration, may be associated with lower risks of hemorrhage. We illustrate vertebrobasilar thrombolysis with intravenous tirofiban, a selective platelet glycoprotein IIb/IIIa receptor antagonist, and discuss the potential thrombolytic properties of this class of antithrombotics.

摘要

在已确诊的脑梗死情况下使用溶栓药物受到出血性转化问题的限制。很少被考虑的新型溶栓方法可能具有较低的出血风险。我们举例说明了使用静脉注射替罗非班（一种选择性血小板糖蛋白IIb/IIIa受体拮抗剂）进行椎基底动脉溶栓，并讨论了这类抗血栓药物潜在的溶栓特性。

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Vertebrobasilar thrombolysis with intravenous tirofiban: case report.静脉注射替罗非班进行椎基底动脉溶栓：病例报告
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Fibrinolysis and Beyond: Bridging the Gap between Local and Systemic Clot Removal.纤维蛋白溶解及其他：弥合局部与全身血栓清除之间的差距。
Front Neurol. 2011 Feb 22;2:7. doi: 10.3389/fneur.2011.00007. eCollection 2011.
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Rescue treatment with intra-arterial tirofiban infusion and emergent carotid stenting.

本文引用的文献

1
The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke.非肽糖蛋白IIb/IIIa血小板受体拮抗剂SM-20302可减少血栓栓塞性中风后组织型纤溶酶原激活剂诱导的脑出血。
Stroke. 2002 Jan;33(1):147-52. doi: 10.1161/hs0102.100530.
2
Rescue treatment with abciximab in acute ischemic stroke.
Neurology. 2001 Jun 12;56(11):1585-7. doi: 10.1212/wnl.56.11.1585.
3
Thrombolysis of extracranial and intracranial arteries after IV abciximab.
Neurology. 2001 Jun 12;56(11):1582-4. doi: 10.1212/wnl.56.11.1582.
4
采用动脉内注射替罗非班并紧急进行颈动脉支架置入术的抢救治疗。
Yonsei Med J. 2008 Oct 31;49(5):857-9. doi: 10.3349/ymj.2008.49.5.857.
Inhibition of platelet-dependent prothrombinase activity and thrombin generation by glycoprotein IIb/IIIa receptor-directed antagonists: potential contributing mechanism of benefit in acute coronary syndromes.糖蛋白IIb/IIIa受体拮抗剂对血小板依赖性凝血酶原酶活性及凝血酶生成的抑制作用：急性冠脉综合征中潜在的有益作用机制
J Thromb Thrombolysis. 2000 Aug;10(1):69-76. doi: 10.1023/a:1018754906289.
5
Effect of aspirin on platelet desaggregation induced by SR121566, a potent GP-IIb/IIIa antagonist.阿司匹林对强效糖蛋白IIb/IIIa拮抗剂SR121566诱导的血小板解聚的影响。
Platelets. 2000 Feb;11(1):43-8. doi: 10.1080/09537100075797.
6
Abciximab in acute ischemic stroke. A randomized, double-blind, placebo-controlled, dose-escalation study.阿昔单抗治疗急性缺血性卒中：一项随机、双盲、安慰剂对照、剂量递增研究。
Stroke. 2000 Mar;31(3):601-9. doi: 10.1161/01.str.31.3.601.
7
Synthetic inhibitors of platelet glycoprotein IIb/IIIa in clinical development.处于临床开发阶段的血小板糖蛋白IIb/IIIa合成抑制剂。
Circulation. 2000 Feb 15;101(6):E76-80. doi: 10.1161/01.cir.101.6.e76.
8
Prevention of thrombosis and enhancement of thrombolysis in rabbits by SR 121787, a glycoprotein II/III antagonist.糖蛋白II/III拮抗剂SR 121787对兔血栓形成的预防及溶栓作用增强
J Pharmacol Exp Ther. 1998 Aug;286(2):670-5.
9
Evaluation of a GPIIb/IIIa antagonist YM337 in a primate model of middle cerebral artery thrombosis.在大脑中动脉血栓形成的灵长类动物模型中对糖蛋白IIb/IIIa拮抗剂YM337的评估。
Eur J Pharmacol. 1998 Mar 19;345(2):185-92. doi: 10.1016/s0014-2999(98)00005-3.
10
A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina.阿司匹林联合替罗非班与阿司匹林联合肝素治疗不稳定型心绞痛的比较。
N Engl J Med. 1998 May 21;338(21):1498-505. doi: 10.1056/NEJM199805213382103.