Arvin Ann M
Department of Pediatric Infectious Diseases, Stanford University, CA 94305-5208, USA.
Herpes. 2002 Jul;9(2):48-50.
The first goal in minimizing herpes simplex virus (HSV) mortality and morbidity in infants is to reduce the risk of acquisition of new infections during pregnancy, especially in late gestation. Antenatal testing does not necessarily predict the risk of transmission to the newborn infant, since this risk is variable. In order to identify newly acquired infection in women who are HSV-seronegative, repeat testing in late pregnancy would need to be offered. In those who are HSV-seropositive, concern for transmission to the infant is likely to result in administration of antiviral drugs to the mother or in Caesarean delivery. The potential consequence is medical intervention for many pregnancies that would not have been complicated by perinatal HSV transmission. Risk - and cost-benefit analyses are needed to assess HSV type-specific serological screening of pregnant women. Practical benefit can be achieved by counselling all pregnant women against oral or unprotected sexual contact during pregnancy.
将单纯疱疹病毒（HSV）导致的婴儿死亡率和发病率降至最低的首要目标是降低孕期尤其是妊娠晚期获得新感染的风险。产前检测不一定能预测传播给新生儿的风险，因为这种风险是可变的。为了识别HSV血清学阴性女性新获得的感染，需要在妊娠晚期进行重复检测。对于HSV血清学阳性的女性，担心病毒传播给婴儿可能会导致给母亲使用抗病毒药物或进行剖宫产。潜在的后果是对许多本不会因围产期HSV传播而出现并发症的妊娠进行医疗干预。需要进行风险和成本效益分析，以评估对孕妇进行HSV特定类型血清学筛查的情况。通过向所有孕妇提供咨询，告诫她们在孕期避免口交或无保护的性接触，可以获得实际的益处。
