Suzuki Mitsuyuki, Okazaki Toshio, Nagai Tatsuo, Törõ Klara, Sétonyi Péter
Department of Forensic Medicine and Science, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa Prefecture 228-8555, Japan.
FEMS Immunol Med Microbiol. 2002 Jul 12;33(3):215-8. doi: 10.1111/j.1574-695X.2002.tb00593.x.
In this study, we screened serum samples for transient hyperphosphatasemia (TH) using cellulose acetate membrane electrophoresis over a period of 3 years. In the patients found to suffer from TH, we examined the relationship between the clinical condition and viral infection. The frequency of TH was 0.26%, and all of the cases detected were in infants or young children. The female to male ratio of TH was 1.29/1. While there was no clear seasonal fluctuation or periodicity in the appearance of TH, two peaks were recognized in spring and autumn. Research on the clinical manifestations clarified that most of the TH cases had infectious diseases of the upper airways accompanied by symptoms of fever and diarrhea. We examined antibody titers for viruses causing upper airway infectious diseases and identified antibodies for enteroviruses such as Echo 22, Entero 71, and Coxsackie B4. Our results suggested that TH might be caused by an infection of the enterovirus group.
在本研究中，我们在3年的时间里使用醋酸纤维素膜电泳对血清样本进行了短暂性高磷酸酶血症（TH）筛查。在被发现患有TH的患者中，我们研究了临床状况与病毒感染之间的关系。TH的发生率为0.26%，所有检测到的病例均为婴儿或幼儿。TH的男女比例为1.29/1。虽然TH的出现没有明显的季节性波动或周期性，但在春季和秋季出现了两个高峰。对临床表现的研究表明，大多数TH病例患有上呼吸道传染病，并伴有发热和腹泻症状。我们检测了引起上呼吸道传染病的病毒的抗体滴度，并鉴定出了针对埃可病毒22型、肠道病毒71型和柯萨奇B4病毒等肠道病毒的抗体。我们的结果表明，TH可能是由肠道病毒组感染引起的。
