Dori Neta, Levi Lily, Stam Tamar, Sukhotnik Igor, Shaoul Ron
Department of Pediatrics Pediatric Surgery, Bnai Zion Medical Center, Maccabi Health Services, Haifa, Israel.
Pediatr Int. 2010 Dec;52(6):866-71. doi: 10.1111/j.1442-200X.2010.03265.x.
Although transient hyperphosphatasemia (TH) has been well known for decades, its etiology and pathophysiology remain unclear. We aimed to study the clinical characteristics of children diagnosed with TH compared to older studies in order to expand our knowledge and understanding of this condition and to try and find a subgroup of children who are more prone to develop TH.
We retrospectively studied 60 children diagnosed at Maccabi Health Services and Bnai Zion Medical Center, Haifa, Israel with TH between the years 2003-08. One hundred and twenty-two children matched by age, gender and presenting symptoms served as the control group. The patients were divided into four subgroups by their presenting symptoms: infectious disease 33%, failure to thrive 28%, diarrhea 15% and other 23%. The Hydragel 7 ISO-PAL and Hydragel 15 ISO-PAL kits were used for the identification and quantification of ALP isoenzymes in human serum.
The ALP levels of the study group were 805-8619 U\L (mean 2311 U\L), without differences between the subgroups. The mean duration of TH was 12 weeks. ALP isoenzymes levels were measured in one-third of the patients, and showed that the bone isoenzyme was elevated in most. Forty-three (71%) subjects were diagnosed in the second half of the calendar year.
We could not establish an etiological explanation for TH. We presume that it is a complex mechanism in which different stimuli led to upregulation of the enzyme.
尽管短暂性高磷酸酶血症（TH）已为人所知数十年，但其病因和病理生理学仍不清楚。我们旨在研究被诊断为TH的儿童的临床特征，并与以往的研究进行比较，以扩展我们对这种疾病的认识和理解，并试图找出更易发生TH的儿童亚组。
我们回顾性研究了2003年至2008年间在以色列海法的马卡比医疗服务中心和贝纳伊锡安医疗中心被诊断为TH的60名儿童。122名年龄、性别和症状相匹配的儿童作为对照组。根据患儿出现的症状将患者分为四个亚组：传染病33%，发育不良28%，腹泻15%，其他23%。使用Hydragel 7 ISO-PAL和Hydragel 15 ISO-PAL试剂盒对人血清中的碱性磷酸酶同工酶进行鉴定和定量。
研究组的碱性磷酸酶水平为805 - 8619 U\L（平均2311 U\L），各亚组之间无差异。TH的平均持续时间为12周。三分之一的患者检测了碱性磷酸酶同工酶水平，结果显示大多数患者的骨同工酶升高。43名（71%）受试者在日历年下半年被诊断出来。
我们无法为TH确定病因学解释。我们推测这是一种复杂的机制，其中不同的刺激导致了该酶的上调。
