用灭活布鲁氏菌的抗原使小鼠产生获得性细胞抗性的回忆反应。
Recall of acquired cellular resistance in mice by antigens from killed Brucella.
作者信息
Halliburton B L, Hinsdill R D
出版信息
Infect Immun. 1972 Jan;5(1):42-7. doi: 10.1128/iai.5.1.42-47.1972.
Abstract
Mice infected with Brucella abortus 19 were challenged intravenously with Listeria monocytogenes. Spleen assays to determine the number of viable Listeria cells present revealed that these mice were highly resistant to Listeria when challenged on day 17 of the Brucella infection. Resistance was absent in mice challenged on the 5th day and was declining in mice challenged on the 33rd day. Resistance could not be detected by day 49 of the Brucella infection but could be recalled by the injection of antigens from smooth B. abortus 2308. Thus, extracted antigens appeared to be as effective in recall as the live cells used in earlier studies. Similar injections of extracts from rough B. abortus 45/20, or from B. ovis REO 198, were also effective in recalling resistance; this suggests that the smooth surface agglutinogen may be relatively unimportant in recall.
摘要
用流产布鲁氏菌19感染的小鼠经静脉注射单核细胞增生李斯特菌进行攻毒。用于确定存活李斯特菌细胞数量的脾脏检测显示，在布鲁氏菌感染第17天进行攻毒时，这些小鼠对李斯特菌具有高度抗性。在第5天进行攻毒的小鼠中没有抗性，在第33天进行攻毒的小鼠中抗性正在下降。在布鲁氏菌感染第49天时检测不到抗性，但通过注射光滑型流产布鲁氏菌2308的抗原可以恢复抗性。因此，提取的抗原在恢复抗性方面似乎与早期研究中使用的活细胞一样有效。类似地，注射粗糙型流产布鲁氏菌45/20或绵羊布鲁氏菌REO 198的提取物在恢复抗性方面也有效；这表明光滑表面凝集原在恢复抗性方面可能相对不重要。
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