Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.
Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
J Neurotrauma. 2021 Jun 1;38(13):1858-1869. doi: 10.1089/neu.2020.7389. Epub 2021 Feb 10.
Physician-prescribed rest after traumatic brain injury (TBI) is both commonplace and an increasingly scrutinized approach to TBI treatment. Although this practice remains a standard of patient care for TBI, research of patient outcomes reveals little to no benefit of prescribed rest after TBI, and in some cases prolonged rest has been shown to interfere with patient well-being. In direct contrast to the clinical advice regarding physical activity after TBI, animal models of brain injury consistently indicate that exercise is neuroprotective and promotes recovery. Here, we assessed the effect of low and moderate intensity treadmill exercise on functional outcome and hippocampal neural proliferation after brain injury. Using the controlled cortical impact (CCI) mouse model of TBI, we show that 10 days of moderate intensity treadmill exercise initiated after CCI reduces anxiety-like behavior, improves hippocampus-dependent spatial memory, and promotes hippocampal proliferation and newborn neuronal survival. Pathophysiological measures including lesion volume and axon degeneration were not altered by exercise. Taken together, these data reveal that carefully titrated physical activity may be a safe and effective approach to promoting recovery after brain injury.
创伤性脑损伤（TBI）后医生建议休息，这在医学上是常见的，也是 TBI 治疗中越来越受到关注的方法。尽管这种做法仍然是 TBI 患者护理的标准，但对患者预后的研究表明，TBI 后规定的休息几乎没有益处，在某些情况下，长时间的休息会干扰患者的健康。与 TBI 后体力活动的临床建议直接形成对比的是，脑损伤的动物模型一致表明，运动具有神经保护作用，并促进恢复。在这里，我们评估了低强度和中等强度跑步机运动对脑损伤后功能结果和海马神经增殖的影响。使用 TBI 的控制性皮质撞击（CCI）小鼠模型，我们表明，CCI 后开始的 10 天中等强度跑步机运动可减轻焦虑样行为，改善海马依赖性空间记忆，并促进海马增殖和新生神经元存活。运动并未改变包括病变体积和轴突退化在内的病理生理测量指标。总之，这些数据表明，经过精心调整的体育活动可能是促进脑损伤后恢复的一种安全有效的方法。
