Annane Djillali
Intensive Care Department, Raymond Poincaré University Hospital, Garches, France.
Crit Care. 2002 Jun;6(3):190-1. doi: 10.1186/cc1486. Epub 2002 May 9.
Based on several recently completed randomized controlled trials, cortisol replacement is likely to become a standard of care for vasopressor dependent septic shock. Further studies are needed in order to accomplish whether this treatment should be limited to patients with a blunted cortisol response to corticotrophin. Similarly, in patients with severe sepsis who do not need vasopressors, the benefit/risk ratio of cortisol replacement remains to be assessed.
基于最近完成的几项随机对照试验,皮质醇替代疗法可能会成为依赖血管升压药的感染性休克的标准治疗方法。为了确定这种治疗是否应仅限于对促肾上腺皮质激素的皮质醇反应迟钝的患者,还需要进一步研究。同样,在不需要血管升压药的严重脓毒症患者中,皮质醇替代疗法的利弊仍有待评估。