Brzecka A, Piesiak P, Zareba-Bogdał E, Zierkiewicz G, Plamieniak Z
Katedry i Kliniki Chorób Płuc Akademii Medycznej we Wrocławiu.
Pneumonol Alergol Pol. 2001;69(11-12):650-4.
Melatonin is a pineal hormone that regulates sleep and wake status. Melatonin concentrations in blood serum were measured using radioisotope method in 33 males (age 48 +/- 10) with obstructive sleep apnea syndrome. The following melatonin concentrations were measured: 54 +/- 72 pg/ml (9 p.m.) 424 +/- 838 pg/ml (2 a.m.) and 307 +/- 534 pg/ml (6 a.m.). In patients with high peak melatonin concentration (> 200 pg/ml) as compared with the patients with low peak melatonin concentration (< 200 pg/ml) there were higher index of respiratory disorders during sleep (53 +/- 18 vs 38 +/- 20, p < 0.05) and lower minimal SaO2 during sleep apnea (52 +/- 17% vs 70 +/- 10%, p < 0.05); they were also more tired in the morning and were more sleepy during the day (Epworth sleepiness scale 17 +/- 6 vs 11 +/- 6, p < 0.01). In 66% of patients peak melatonin concentration was observed at 2 a.m. In 24% of patients peak melatonin secretion was prolonged to early morning hours.
In most of patients there is peak melatonin excretion at 2 a.m. Patients with high apnea and hypopnea index and daytime sleepiness have high peak melatonin concentrations.
褪黑素是一种调节睡眠和清醒状态的松果体激素。采用放射性同位素法对33名患有阻塞性睡眠呼吸暂停综合征的男性（年龄48±10岁）测定血清中的褪黑素浓度。所测褪黑素浓度如下：晚上9点为54±72 pg/ml，凌晨2点为424±838 pg/ml，早上6点为307±534 pg/ml。与褪黑素峰值浓度低（<200 pg/ml）的患者相比，褪黑素峰值浓度高（>200 pg/ml）的患者睡眠期间呼吸紊乱指数更高（53±18对38±20，p<0.05），睡眠呼吸暂停期间最低血氧饱和度更低（52±17%对70±10%，p<0.05）；他们早上也更疲劳，白天更困倦（爱泼沃斯嗜睡量表评分17±6对11±6，p<0.01）。66%的患者褪黑素峰值浓度出现在凌晨2点。24%的患者褪黑素分泌峰值延长至清晨时段。
大多数患者褪黑素排泄峰值出现在凌晨2点。呼吸暂停和低通气指数高以及白天嗜睡的患者褪黑素峰值浓度高。
