Eloy R, Garaud J C, Moody A, Jaeck D, Grenier J F
Horm Metab Res. 1975 Nov;7(6):461-7. doi: 10.1055/s-0028-1093704.
In the present study using an isolated perfused preparation of canine jejunum and pancreas, an insulin-releasing factor was found in the venous effluent of the jejunum. Insulin secretion by the pancreas rose twofold after 10% glucose was infused in the lumen of the jejunum and remained at a high level even after the stimulus was discontinued. No modification of the exocrine pancreatic secretion occurred during the insulin release, and therefore it seems unlikely that gastrin, secretin or cholecystokinin-pancreozymin were released by the jejunal mucosa. In control experiments the values of hyperglycaemia observed previously and intraluminal hyperosmolarity were tested: at these levels, they did not affect insulin secretion. The nature of this intestinal insulin-releasing factor remains unknown however, but may be identifiable when intestinal hormones in blood can be assayed reliably.
在本研究中，使用犬空肠和胰腺的离体灌流制剂，在空肠静脉流出液中发现了一种胰岛素释放因子。当在空肠腔内注入10%葡萄糖后，胰腺的胰岛素分泌增加了两倍，并且即使在刺激停止后仍保持在高水平。在胰岛素释放过程中，胰腺外分泌没有发生改变，因此空肠黏膜不太可能释放胃泌素、促胰液素或缩胆囊素-促胰酶素。在对照实验中，对先前观察到的高血糖值和管腔内高渗情况进行了测试：在这些水平下，它们并不影响胰岛素分泌。然而，这种肠道胰岛素释放因子的性质仍然未知，但当血液中的肠道激素能够可靠检测时，它可能是可以识别的。
