Chung Yoon Hee, Shin Chung Min, Joo Kyeung Min, Kim Myeung Ju, Cha Choong Ik
Department of Anatomy, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, South Korea.
Brain Res. 2002 Aug 16;946(2):307-13. doi: 10.1016/s0006-8993(02)03041-x.
In the present study, we investigated age-related changes in IGF-I receptor localization in the cerebral cortex and hippocampus of Sprague-Dawley rats using immunohistochemistry. In the cerebral cortex of adult rats, weakly stained cells were seen in layers II-III and layer V/VI in several cortical regions. In aged rats, there was a significant increase in IGF-I receptor immunoreactivity in the pyramidal cells in the same cortical regions. In the hippocampus of adult rats, several moderately stained neurons were seen in CA1-3 areas and the dentate gyrus. Levels of IGF-I receptor protein increased substantially with age in the CA3 area of the hippocampus. Our first morphological data concerning the differential regulation of IGF-I receptors in aged cerebral cortex and hippocampus may provide insights into age-related changes in trophic support as well as basic knowledge required for the study of neurodegenerative diseases such as Alzheimer's disease.
在本研究中，我们使用免疫组织化学方法研究了Sprague-Dawley大鼠大脑皮层和海马中IGF-I受体定位的年龄相关变化。在成年大鼠的大脑皮层中，在几个皮层区域的II-III层和V/VI层可见弱染色细胞。在老年大鼠中，相同皮层区域的锥体细胞中IGF-I受体免疫反应性显著增加。在成年大鼠的海马中，在CA1-3区域和齿状回可见几个中度染色的神经元。海马CA3区域中IGF-I受体蛋白水平随年龄显著增加。我们关于老年大脑皮层和海马中IGF-I受体差异调节的首个形态学数据，可能为营养支持的年龄相关变化提供见解，以及为研究诸如阿尔茨海默病等神经退行性疾病所需的基础知识。
