白细胞介素-1β和白细胞介素-6基因多态性是复发性阿弗他口炎（RAS）发生的显著风险因素。
IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS).
作者信息
Bazrafshani M R, Hajeer A H, Ollier W E R, Thornhill M H
机构信息
ARC Epidemiology Unit, University of Manchester, UK.
出版信息
Genes Immun. 2002 Aug;3(5):302-5. doi: 10.1038/sj.gene.6363882.
Recurrent aphthous stomatitis (RAS) is an, ulcerative condition of the mouth, with a polygenic mode of inheritance in which cytokines are thought to play an important role. Ninety-one RAS patients and 91 controls were genotyped for known IL-1A, IL-1B, IL-1RN and IL-6 gene polymorphisms. Inheritance of the G allele of the IL-1B -511 polymorphism was strongly associated with RAS (OR = 2.5, P < 0.00002), with increased numbers of G/G homozygotes (OR = 4.5, P < 0.0005). The G allele of IL-6 -174 also occurred more frequently in RAS (OR = 2.6, P < 0.0001) with greatest risk associated with G/G homozygosity (OR = 3.4, P < 0.0001). IL-1RN VNTR 1/1 homozygotes also occurred more frequently in RAS (OR = 2.0, P < 0.02). Inheritance of the G/G genotype of both IL-1B and IL-6 was a particularly strong predictor for RAS (OR = 8.5).
复发性阿弗他口炎（RAS）是一种口腔溃疡性疾病，具有多基因遗传模式，其中细胞因子被认为起重要作用。对91例RAS患者和91例对照进行已知的IL-1A、IL-1B、IL-1RN和IL-6基因多态性基因分型。IL-1B -511多态性的G等位基因遗传与RAS密切相关（OR = 2.5，P < 0.00002），G/G纯合子数量增加（OR = 4.5，P < 0.0005）。IL-6 -174的G等位基因在RAS中也更频繁出现（OR = 2.6，P < 0.0001），与G/G纯合性相关的风险最高（OR = 3.4，P < 0.0001）。IL-1RN VNTR 1/1纯合子在RAS中也更频繁出现（OR = 2.0，P < 0.02）。IL-1B和IL-6的G/G基因型遗传是RAS的一个特别强的预测指标（OR = 8.5）。
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