LeBlanc Stephen J, Duffield Todd F, Leslie Ken E, Bateman Ken G, TenHag Jeromy, Walton John S, Johnson Walter H
Department of Population Medicine, University of Guelph, Ontario, Canada.
J Dairy Sci. 2002 Jun;85(6):1416-26. doi: 10.3168/jds.S0022-0302(02)74209-4.
The objective of this study was to investigate parenteral vitamin E for the prevention of peripartum disease in dairy cows. A randomized clinical trial was conducted in 21 commercial dairy herds. Cows (n = 1142) were randomly assigned to receive either a single subcutaneous injection of 3000 IU of vitamin E, or placebo, 1 wk before expected calving. Serum alpha-tocopherol was significantly increased in treated cows at 7 and 14 d, but not at 21 d after injection. Overall, there were no significant differences between treatment groups in the incidence of retained placenta, clinical mastitis, metritis, endometritis, ketosis, displaced abomasum, or lameness. However, there was a conditional benefit of treatment for reduction of the incidence of retained placenta. Cows with marginal pretreatment vitamin E status (serum alpha-tocopherol to cholesterol mass ratio < 2.5 x 10(-3)) that received an injection of vitamin E tended to have reduced risk of retained placenta. However, in cows with adequate serum vitamin E, there was no reduction in the incidence of any disease. For clinical application, primiparous animals were most likely to benefit from prepartum injection of vitamin E.
本研究的目的是调查胃肠外补充维生素E对预防奶牛围产期疾病的作用。在21个商业奶牛场进行了一项随机临床试验。在预计产犊前1周，将1142头奶牛随机分为两组，分别接受一次皮下注射3000 IU维生素E或安慰剂。注射后7天和14天，治疗组奶牛血清α-生育酚显著升高，但21天时未升高。总体而言，治疗组和对照组在胎衣不下、临床型乳房炎、子宫炎、子宫内膜炎、酮病、真胃移位或跛行的发病率上无显著差异。然而，维生素E治疗对降低胎衣不下的发病率有一定益处。产前维生素E水平处于临界值（血清α-生育酚与胆固醇质量比<2.5×10⁻³）的奶牛，注射维生素E后胎衣不下的风险有降低趋势。然而，血清维生素E水平充足的奶牛，任何疾病的发病率均未降低。在临床应用中，初产动物最有可能从产前注射维生素E中获益。
