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本文引用的文献

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A novel superoxide-producing NAD(P)H oxidase in kidney.
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2
NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells.NADPH氧化酶亚基，gp91（phox）同源物，在人结肠上皮细胞中优先表达。
Gene. 2000 Aug 22;254(1-2):237-43. doi: 10.1016/s0378-1119(00)00258-4.
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NADPH oxidase subunits and superoxide production in porcine pulmonary artery endothelial cells.
Histochem Cell Biol. 2000 Jul;114(1):29-37. doi: 10.1007/s004180000160.
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Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells.内皮细胞中NAD(P)H氧化酶成分gp91-噬血细胞氧化酶和p22-噬血细胞氧化酶的分子特征及定位
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Oxidative stress and expression of p22phox are involved in the up-regulation of tissue factor in vascular smooth muscle cells in response to activated platelets.氧化应激和p22phox的表达参与了血管平滑肌细胞中组织因子因活化血小板而发生的上调过程。
FASEB J. 2000 Aug;14(11):1518-28.
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A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall.一种在内皮细胞中选择性表达的含gp91phox的NADPH氧化酶是动脉壁中氧自由基产生的主要来源。
Circ Res. 2000 Jul 7;87(1):26-32. doi: 10.1161/01.res.87.1.26.
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Identification of renox, an NAD(P)H oxidase in kidney.肾脏中NAD(P)H氧化酶Renox的鉴定。
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Endothelial cell oxidant production: effect of NADPH oxidase inhibitors.
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Role of the vascular NADH/NADPH oxidase system in atherosclerosis.血管NADH/NADPH氧化酶系统在动脉粥样硬化中的作用。
Ann N Y Acad Sci. 2000 May;902:241-7; discussion 247-8. doi: 10.1111/j.1749-6632.2000.tb06319.x.
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Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice.由于吞噬细胞NADPH氧化酶缺乏导致超氧化物生成受损，无法抑制小鼠的动脉粥样硬化。
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NADPH氧化酶：血管系统中活性氧的新来源？

NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?

作者信息

Van Heerebeek L, Meischl C, Stooker W, Meijer C J L M, Niessen H W M, Roos D

机构信息

Institute of Cardiovascular Research, Free University Medical Center, Amsterdam, The Netherlands.

出版信息

J Clin Pathol. 2002 Aug;55(8):561-8. doi: 10.1136/jcp.55.8.561.

DOI:10.1136/jcp.55.8.561
PMID:12147646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1769734/
Abstract

Reactive oxygen species play an important role in a variety of (patho)physiological vascular processes. Recent publications have produced evidence of a role for putative non-phagocyte NADP oxidase(s) in the vascular production of reactive oxygen species. In the present review, we discuss the detection of the different components of NADP oxidase(s) in the vascular system, together with the putative role of reactive oxygen species produced by vascular NADPH oxidase(s), in both in vitro and in vivo studies.

摘要

活性氧在多种（病理）生理血管过程中发挥重要作用。最近的出版物提供了证据，表明假定的非吞噬细胞NADP氧化酶在血管活性氧的产生中起作用。在本综述中，我们讨论了在体外和体内研究中，血管系统中NADP氧化酶不同组分的检测，以及血管NADPH氧化酶产生的活性氧的假定作用。