Spiropoulos John, Turnbull Douglass M, Chinnery Patrick F
Department of Reproductive Medicine, The University of Newcastle-upon-Tyne, UK.
Mol Hum Reprod. 2002 Aug;8(8):719-21. doi: 10.1093/molehr/8.8.719.
Very low levels of somatic mitochondrial (mt)DNA deletions have been identified in the semen of infertile men. It has been suggested that these mutations cause infertility through an effect on sperm motility, but there has been no direct evidence to show that mutant mtDNA can affect sperm function. We have carried out semen analysis on a male harbouring the A3243G mtDNA mutation and show that high levels of mutant mtDNA strongly correlate with low sperm motility.
在不育男性的精液中已发现极低水平的体细胞线粒体（mt）DNA缺失。有人认为这些突变通过影响精子活力导致不育，但尚无直接证据表明突变的mtDNA会影响精子功能。我们对一名携带A3243G mtDNA突变的男性进行了精液分析，结果显示高水平的突变mtDNA与低精子活力密切相关。
