Poorhassan Mahnaz, Gholaminejhad Morteza, Ahmadi Houssein, Mehboudi Leila, Chahar Kameh Mahdis, Pirani Maryam, Hassanzadeh Gholamreza
Artificial Intelligence Department, Smart University of Medical Sciences, Tehran, Iran.
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2022 Dec 24;13:e75. doi: 10.34172/jlms.2022.75. eCollection 2022.
About 50% of infertility problems are related to male factors and reduced sperm motility. The important factor that affects the structure and function of sperm is reactive oxygen species (ROS), and over-concentration of ROS reduces the quality and motility of sperm. Photobiomodulation therapy (PBMT) using red to near-infrared (NIR) light is useful in oxidative stress restoration. It plays a therapeutic role in disorders such as asthenospermia, oligospermia cases, and cryopreserved sperm. It also enhances the metabolic capacity of sperm and increases the low-level and non-harmful intracellular content of Ca, nitric oxide (NO), and ROS in the stressed cells. Likewise, it modulates survival intracellular pathways and maintains the motility, viability, DNA, and acrosome integrity of sperm. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of semen PBMT.
约50%的不孕问题与男性因素及精子活力降低有关。影响精子结构和功能的重要因素是活性氧（ROS），ROS浓度过高会降低精子质量和活力。使用红光至近红外（NIR）光的光生物调节疗法（PBMT）有助于恢复氧化应激。它在弱精子症、少精子症病例以及冷冻保存精子等病症中发挥治疗作用。它还能增强精子的代谢能力，并增加应激细胞中低水平且无害的细胞内钙、一氧化氮（NO）和ROS含量。同样，它调节细胞内的存活途径，并维持精子的活力、生存能力、DNA和顶体完整性。本文综述了关于精液PBMT疗效的最新临床前和临床证据。
