Krueger Robert F, Hicks Brian M, Patrick Christopher J, Carlson Scott R, Iacono William G, McGue Matt
Department of Psychology, University of Minnesota, Minneapolis 55455-0344, USA.
J Abnorm Psychol. 2002 Aug;111(3):411-24.
A hierarchical biometric model is presented of the origins of comorbidity among substance dependence, antisocial behavior, and a disinhibited personality style. The model posits a spectrum of personality and psychopathology, united by an externalizing factor linked to each phenotype within the spectrum, as well as specific factors that account for distinctions among phenotypes within the spectrum. This model fit self-report and mother-report data from 1,048 male and female 17-year-old twins. The variance of the externalizing factor was mostly genetic, but both genetic and environmental factors accounted for distinctions among phenotypes within the spectrum. These results reconcile evidence for general and specific causal factors within the externalizing spectrum and offer the externalizing factor as a novel target for future research.
提出了一种关于物质依赖、反社会行为和放纵型人格风格共病起源的分层生物模型。该模型假设了一系列人格和精神病理学特征，由与该范围内每个表型相关的外化因素以及解释该范围内表型差异的特定因素统一起来。该模型拟合了1048名17岁男性和女性双胞胎的自我报告和母亲报告数据。外化因素的方差主要是遗传性的，但遗传和环境因素都解释了该范围内表型之间的差异。这些结果调和了外化范围内一般和特定因果因素的证据，并将外化因素作为未来研究的一个新目标。
