Kirisci Levent, Reynolds Maureen, Vanyukov Michael, Fabian Tanya, Tarter Ralph
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.
Department of Pharmaceutical Sciences, University of Pittsburgh.
Exp Clin Psychopharmacol. 2025 Aug;33(4):407-415. doi: 10.1037/pha0000776. Epub 2025 May 5.
This study prospectively examined the interplay of culturally ingrained beliefs regarding the benefits of substance use, social milieu featured by disengaged parents and deviant friends, and behavior undercontrol on the development of substance use disorder (SUD) by early adulthood. The sample at baseline consisted of 497 youths between 10 and 12 years of age. Subsequent evaluations were conducted when the participants attained 12-14, 16, and 22 years of age. The research protocol was composed of self-report, informant report, and performance measures. Positive beliefs about substance use effects were evaluated using the Adolescent Alcohol and Drug Expectancy Questionnaire. The social milieu was characterized by the environtype index encompassing parental engagement and normative behavior of friends. Behavior control was quantified using the neurobehavior disinhibition scale. Substance use frequency and intensity of reward experience during consumption were recorded using the Drug Use Screening Inventory and the Substance Use Questionnaire. The outcome variable, lifetime SUD, was diagnosed using the Structured Clinical Interview for Diagnosis. Structural equation modeling evaluated the association among these variables. Beliefs regarding the benefits of consumption mediated the associations of childhood social milieu with substance use frequency and reward intensity during the transition into adolescence. Reward intensity during this developmental period predicted consumption frequency and severity of behavior undercontrol in midadolescence, which conjointly predicted SUD by early adulthood. This study demonstrated that SUD manifested by early adulthood culminates from the coaction of acquired cultural beliefs, social context facilitating access to addictive chemicals, and suboptimal psychological self-regulation. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
本研究前瞻性地考察了关于物质使用益处的文化固有信念、以疏离的父母和偏差朋友为特征的社会环境以及行为自控能力对成年早期物质使用障碍（SUD）发展的相互作用。基线样本包括497名10至12岁的青少年。在参与者达到12 - 14岁、16岁和22岁时进行后续评估。研究方案由自我报告、 informant报告和表现测量组成。使用青少年酒精和药物预期问卷评估对物质使用效果的积极信念。社会环境通过包含父母参与和朋友规范行为的环境类型指数来表征。使用神经行为去抑制量表对行为控制进行量化。使用药物使用筛查量表和物质使用问卷记录物质使用频率和消费期间奖励体验的强度。结果变量，即终生SUD，使用结构化临床诊断访谈进行诊断。结构方程模型评估这些变量之间的关联。关于消费益处的信念在童年社会环境与青少年过渡期间物质使用频率和奖励强度的关联中起中介作用。这个发育阶段的奖励强度预测了青少年中期的消费频率和行为自控不足的严重程度，这两者共同预测了成年早期的SUD。本研究表明，成年早期出现的SUD是由习得的文化信念、便于获取成瘾性化学物质的社会环境以及欠佳的心理自我调节共同作用的结果。（PsycInfo数据库记录（c）2025美国心理学会，保留所有权利）
