Foltinová Janka, Schrott-Fischer Annelies, Zilínek Viliam, Foltin Viktor, Freysinger Wolfgang
Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Laryngoscope. 2002 Apr;112(4):713-20. doi: 10.1097/00005537-200204000-00022.
OBJECTIVES/HYPOTHESIS: The differentiated character of changes in the mucous relief of the trachea as induced by air containing pollutants from the wastes of nickel-, mercury-, and cement-producing plants and by Candida albicans occurring in the waste disposal site of a large town are identified. The trachea was chosen because it is the entrance gate for the penetration of polluted air into the lungs. Changes on the trachea influence the character and extent of changes in lungs.
Histological study with Viennese grey strain laboratory rabbits and rats caught directly on an investigated site.
We present new results of the functional morphology of the respiratory system as the results of scanning and transmission electron microscopy studies that can reveal character and range of damage of mucosal relief of trachea relevant to the functional dynamics of mucociliary clearance. Under physiological conditions this mechanism allows that only respirable dust particles enter the deep respiratory tract.
In case of a damaged tracheal relief because of exposure to various aerosols, the functional morphology is changed, which aids in understanding the mechanisms damaging to mucociliary clearance induced by living in heavily polluted areas.
Understanding of these morphological changes on base of detailed electron microscopic findings sheds new light on elaborating novel diagnostic methods for clinical practice.
目的/假设：确定来自镍、汞和水泥厂废料的含污染物空气以及大城市垃圾处理场中出现的白色念珠菌所诱发的气管黏膜形态变化的特征。选择气管是因为它是污染空气进入肺部的入口。气管的变化会影响肺部变化的特征和程度。
对直接在调查地点捕获的维也纳灰品系实验兔和大鼠进行组织学研究。
我们展示了呼吸系统功能形态学的新结果，这些结果来自扫描和透射电子显微镜研究，能够揭示与黏液纤毛清除功能动力学相关的气管黏膜形态损伤的特征和范围。在生理条件下，该机制使得只有可吸入的尘埃颗粒能够进入下呼吸道。
由于暴露于各种气溶胶而导致气管形态受损时，功能形态会发生变化，这有助于理解生活在重度污染地区对黏液纤毛清除功能造成损害的机制。
基于详细的电子显微镜观察结果对这些形态变化的理解，为临床实践中开发新的诊断方法提供了新的思路。
