Jeong Hun-Jin, Nam Hyoryung, Jang Jinah, Lee Seung-Jae
Department of Mechanical Engineering, Wonkwang University, 54538, Iksan-daero 460, Iksan-si, Jeollabuk-do, Korea.
Department of Creative IT Engineering, Pohang University of Science and Technology, 37673, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, Korea.
Bioengineering (Basel). 2020 Mar 31;7(2):32. doi: 10.3390/bioengineering7020032.
It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-shaped tissues and organs have their own design with target-specific mechanical and biological properties. Therefore, the customized geometrical and physiological environment is required as one of the most critical factors for functional tissue regeneration. 3D bioprinting technology has been receiving attention for the fabrication of patient-tailored and complex-shaped free-form architecture with high reproducibility and versatility. Printable biocomposite inks that can facilitate to build tissue constructs with polymeric frameworks and biochemical microenvironmental cues are also being actively developed for the reconstruction of functional tissue. In this review, we delineated the state-of-the-art of 3D bioprinting techniques specifically for tubular tissue and organ regeneration. In addition, this review described biocomposite inks, such as natural and synthetic polymers. Several described engineering approaches using 3D bioprinting techniques and biocomposite inks may offer beneficial characteristics for the physiological mimicry of human tubular tissues and organs.
用传统生物制造技术（如静电纺丝、细胞片工程和铸模）制造管状组织和器官（如气管、血管和食管组织）很困难，因为这些技术有复杂的多个过程。此外，管状组织和器官有其自身具有特定目标机械和生物学特性的设计。因此，定制的几何和生理环境作为功能组织再生的最关键因素之一是必需的。3D生物打印技术因能制造具有高再现性和多功能性的患者定制复杂形状自由形式结构而受到关注。可促进构建具有聚合物框架和生化微环境线索的组织构建体的可打印生物复合墨水也正在被积极开发用于功能性组织的重建。在本综述中，我们阐述了专门用于管状组织和器官再生的3D生物打印技术的最新进展。此外，本综述描述了生物复合墨水，如天然和合成聚合物。所描述的几种使用3D生物打印技术和生物复合墨水的工程方法可能为人类管状组织和器官的生理模拟提供有益特性。
