Messire Gatien, Ferreira Véronique, Caillet Emma, Bodin Lyana, Auville Amélia, Berteina-Raboin Sabine
Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067 Orléans, France.
Molecules. 2023 Oct 3;28(19):6924. doi: 10.3390/molecules28196924.
Following the work already carried out in our laboratory on eucalyptol, a new green solvent derived from biomass, we are now looking at sabinene as another new green solvent. Sabinene is also derived from biomass, has no known toxicity and can be recycled by distillation. We have shown that it can be used as it is or distilled to synthesize thiazolo[5,4-]pyridine heterocycles by thermal activation or microwave irradiation. This new solvent was compared with various conventional and green solvents. The conditions were optimised to enable us to carry out the syntheses in satisfactory yields, and we were able to show that sabinene, a natural bicyclic monoterpene, could be used effectively as a solvent.
继我们实验室对桉叶油素（一种源自生物质的新型绿色溶剂）开展的工作之后，我们现在将桧烯视为另一种新型绿色溶剂。桧烯同样源自生物质，无毒且可通过蒸馏回收利用。我们已经证明，它可以直接使用，也可以通过蒸馏，经热活化或微波辐射来合成噻唑并[5,4 - ]吡啶杂环。我们将这种新型溶剂与各种传统溶剂和绿色溶剂进行了比较。对条件进行了优化，以使我们能够以令人满意的产率进行合成，并且我们能够证明，天然双环单萜桧烯可以有效地用作溶剂。
