Zawacki Tricia M, Grace Janet, Paul Robert, Moser David J, Ott Brian R, Gordon Norman, Cohen Ronald A
Department of Psychology, Georgia State University, Atlanta, Georgia 30303, USA.
J Neuropsychiatry Clin Neurosci. 2002 Summer;14(3):296-302. doi: 10.1176/jnp.14.3.296.
The relationship of behavioral disturbance and dementia severity to activities of daily living (ADLs) in vascular dementia (VaD) was examined in baseline data for 29 VaD patients. A series of stepwise regression analyses was conducted to examine the extent to which dementia severity, apathy, disinhibition, and executive dysfunction predict ADLs (total, basic, and instrumental). For total ADLs, apathy accounted for 36% of the variance and dementia severity accounted for an additional 15%. For basic ADLs, apathy accounted for 27% of the variance. Dementia severity, executive dysfunction, and disinhibition were not significantly associated with basic ADLs. For instrumental ADLs, dementia severity accounted for 37% of the variance and apathy accounted for an additional 14%. These findings highlight the importance of apathy as an independent factor associated with functional independence beyond general cognitive abilities.
在29例血管性痴呆（VaD）患者的基线数据中，研究了行为障碍和痴呆严重程度与日常生活活动（ADL）之间的关系。进行了一系列逐步回归分析，以检验痴呆严重程度、淡漠、脱抑制和执行功能障碍对ADL（总体、基本和工具性）的预测程度。对于总体ADL，淡漠占方差的36%，痴呆严重程度又占15%。对于基本ADL，淡漠占方差的27%。痴呆严重程度、执行功能障碍和脱抑制与基本ADL无显著相关性。对于工具性ADL，痴呆严重程度占方差的37%，淡漠又占14%。这些发现突出了淡漠作为一个独立因素的重要性，它与超出一般认知能力的功能独立性相关。
