Vanderbilt University School of Medicine, Vanderbilt Health One Hundred Oaks, Center for Surgical Weight Loss, Nashville, TN 37204, USA.
Eat Weight Disord. 2011 Jun;16(2):e121-6. doi: 10.1007/BF03325317.
This study examined whether severity of binge eating is associated with dysfunction in behaviors mediated by the three main areas of the prefrontal cortex (PFC).
One hundred fifty-one adults (mean BMI=49.50) were classified into three groups based on the presence and severity of binge eating behaviors: Binge Eating Disorder (BED) group (N=22), Binge Eating Prone (BEP) group (N=47), and non-Eating Disorder (non-ED) group (N=82). Participants completed the Frontal Systems Behavior Scale (FrSBe), a widely used measure of neurobehavioral traits associated with the three primary regions of the PFC corresponding with the behavioral traits of apathy, disinhibition, and executive dysfunction.
The BED and BEP groups scored significantly higher than the non-ED group on the three FrSBe subscales, as well as the FrSBe Total score. There were no significant correlations between the FrSBe and participant BMI.
As expected, individuals who engaged in binge eating endorsed greater PFC dysfunction than those who did not binge eat. These results provide a complement to studies utilizing neuroimaging and neuropsychological methodologies and further support for the role of prefrontal systems in the regulation of eating behavior.
本研究旨在探讨暴食行为的严重程度是否与前额叶皮层（PFC）三个主要区域介导的行为障碍有关。
根据是否存在暴食行为及其严重程度，将 151 名成年人（平均 BMI=49.50）分为三组：暴食障碍（BED）组（N=22）、暴食倾向（BEP）组（N=47）和非饮食障碍（非 ED）组（N=82）。参与者完成了额叶系统行为量表（FrSBe），这是一种广泛用于测量与 PFC 三个主要区域相关的神经行为特征的量表，与冷漠、抑制障碍和执行功能障碍的行为特征相对应。
BED 和 BEP 组在 FrSBe 的三个分量表以及 FrSBe 总分上的得分显著高于非 ED 组。FrSBe 与参与者 BMI 之间无显著相关性。
正如预期的那样，暴食者的 PFC 功能障碍比不暴食者更严重。这些结果为利用神经影像学和神经心理学方法的研究提供了补充，并进一步支持了前额叶系统在调节进食行为中的作用。
