Klapdor R, Schliewe J, Valerius H
Res Exp Med (Berl). 1975 Dec 30;166(3):241-51. doi: 10.1007/BF01852637.
The mechanisms of bile excretion are investigated in 27 experiments in 21 mini-pigs. The results confirm the known three fractions of bile flow for mini-pigs, too: a canalicular bile acid dependent, a canalicular bile acid independent and a ductular bile acid independent bile flow. These different fractions of bile flow may be stimulated either by taurocholate, by phenobarbital and ioglycamide or by secretin and pancreozymin. The total bile acid pool amounts 4,4 mMol. Measurements of its distribution over the gallbladder and the enterohepatic circulation after fasting for 18-24 hours emphasize the importance of the gallbladder resp. the fasting as factors that may be responsible for the secretion of lithogenic bile.
在对21头小型猪进行的27次实验中研究了胆汁排泄机制。结果也证实了小型猪已知的三种胆汁流部分：一种是胆小管胆汁酸依赖性胆汁流、一种是胆小管胆汁酸非依赖性胆汁流和一种是胆小管后段胆汁酸非依赖性胆汁流。这些不同部分的胆汁流可被牛磺胆酸盐、苯巴比妥和碘甘酰胺或被促胰液素和缩胆囊素刺激。总胆汁酸池为4.4毫摩尔。在禁食18 - 24小时后对其在胆囊和肠肝循环中的分布进行的测量强调了胆囊或禁食作为可能导致致石性胆汁分泌的因素的重要性。
