Klapdor R, Schulz T, Sepehr H
Res Exp Med (Berl). 1978 Aug 15;173(2):203-8. doi: 10.1007/BF01851878.
The effects of an intravenous infusion of cholecystokinin-pancreozymin on bile secretion were studied in 13 unanesthetized and cholecystectomized piglets. The results demonstrate that CCK-PZ induces a significant increase of bile flow and bile salt excretion. The excretion patterns for bilirubin and Ioglycamide, however, showed a slight but not significant decrease. Peripheral hemodynamic parameters remained unchanged. A detailed analysis of these results suggests that CCK-PZ induces an increase of biliary bile salt secretion by stimulation of intestinal motility and enhancement of bile salt circulation within the enterohepatic circulation (EHC). In combination with previous studies on the effects of spasmolytics on biliary bile salt excretion these results therefore emphasize, that the intestinal motility and transit time might play a role in the physiology and pathophysiology of biliary bile salt secretion.
在13只未麻醉且已切除胆囊的仔猪中，研究了静脉输注胆囊收缩素-促胰酶素对胆汁分泌的影响。结果表明，胆囊收缩素-促胰酶素可显著增加胆汁流量和胆盐排泄。然而，胆红素和碘甘脲的排泄模式显示略有下降，但不显著。外周血流动力学参数保持不变。对这些结果的详细分析表明，胆囊收缩素-促胰酶素通过刺激肠道蠕动和增强肠肝循环（EHC）内的胆盐循环，诱导胆汁胆盐分泌增加。因此，结合先前关于解痉药对胆汁胆盐排泄影响的研究，这些结果强调，肠道蠕动和转运时间可能在胆汁胆盐分泌的生理和病理生理过程中发挥作用。
