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对由I-A亚区编码的小鼠Ia分子进行部分N端氨基酸序列分析和比较胰蛋白酶肽图分析。

Partial N-terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I-A subregion.

作者信息

Cecka J M, Mc Millan M, Murphy D B, McDevitt H O, Hood L

出版信息

Eur J Immunol. 1979 Dec;9(12):955-63. doi: 10.1002/eji.1830091209.

DOI:10.1002/eji.1830091209
PMID:121573
Abstract

The partial N-terminal amino acid sequences and tryptic peptide maps of I-A subregion products from the H-2b, H-2d, H-2k and H-2s haplotypes demonstrate that haplotype-associated differences are present in both alpha and beta polypeptides. The genetic and evolutionary implications of these multiple amino acid substitutions and the homology relationships among Ia molecules from human, guinea pig and the I-E subregion of the mouse are discussed.

摘要

来自H-2b、H-2d、H-2k和H-2s单倍型的I-A亚区产物的部分N端氨基酸序列和胰蛋白酶肽图表明，α和β多肽中均存在与单倍型相关的差异。本文讨论了这些多个氨基酸取代的遗传和进化意义，以及来自人类、豚鼠和小鼠I-E亚区的Ia分子之间的同源关系。

相似文献

1
Partial N-terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I-A subregion.对由I-A亚区编码的小鼠Ia分子进行部分N端氨基酸序列分析和比较胰蛋白酶肽图分析。
Eur J Immunol. 1979 Dec;9(12):955-63. doi: 10.1002/eji.1830091209.
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引用本文的文献

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Immunogenetics. 1981 Mar 1;12(5-6):569-77. doi: 10.1007/BF01561697.
2
Isolation and identification of a cDNA clone corresponding to an HLA-DR antigen beta chain.一个与HLA - DR抗原β链对应的cDNA克隆的分离与鉴定。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1703-7. doi: 10.1073/pnas.79.6.1703.
3
Structure of murine Ia antigens. Two dimensional electrophoretic analyses and high pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide.
小鼠Ia抗原的结构。I-A和I-E亚区产物以及一种相关的恒定多肽的二维电泳分析和高压液相色谱胰蛋白酶肽图谱。
J Exp Med. 1981 Apr 1;153(4):936-50. doi: 10.1084/jem.153.4.936.
4
H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. VI. H-2Kb mutants differentially regulate the immune response to the H-4.2 alloantigen.H-2对针对单一非H-2同种异体抗原反应中细胞间相互作用的影响。VI. H-2Kb突变体对H-4.2同种异体抗原免疫反应的差异调节。
Immunogenetics. 1983;17(2):109-23. doi: 10.1007/BF00364751.
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Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.细胞类型特异性cDNA探针与小鼠I区：Adα的定位与方向
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2194-8. doi: 10.1073/pnas.81.7.2194.
6
The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.小鼠Iaα链，即Eα和Aα，表现出惊人程度的序列同源性。
Proc Natl Acad Sci U S A. 1983 Jan;80(2):534-8. doi: 10.1073/pnas.80.2.534.
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Serological cross-reactivity between products of separate I regions.不同I区产物之间的血清学交叉反应性。
Immunogenetics. 1982 Jan;15(1):71-7. doi: 10.1007/BF00375504.