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不同I区产物之间的血清学交叉反应性。

Serological cross-reactivity between products of separate I regions.

作者信息

Birnbaum D, Pla M, Colombani M, Colombani J

出版信息

Immunogenetics. 1982 Jan;15(1):71-7. doi: 10.1007/BF00375504.

DOI:10.1007/BF00375504
PMID:6177629
Abstract

A B10.S(7R) anti-B10.S(9R) serum (anti-IJEkCd) contained, as expected, antibodies specific for the I-E-subregion-encoded determinant Ia.7. However, tests on recombinant haplotypes demonstrated a series of unexpected weak extrareactions which could be interpreted to be directed against antigenic determinants encoded in the I-A subregion of the H-2 complex. The same type of extrareaction was observed in eluates from I-As, I-Ek cells coated with A.TH anti-A.TL (I-As, I-Ek anti-I-Ak, I-Ek) serum. This reactivity in serum and eluates could be interpreted as cross-reactivity between products of the I-E and I-A subregions.

摘要

正如预期的那样，一种B10.S(7R)抗B10.S(9R)血清（抗-IJEkCd）含有针对I-E亚区编码的决定簇Ia.7的特异性抗体。然而，对重组单倍型的检测显示出一系列意外的微弱额外反应，这些反应可被解释为针对H-2复合体I-A亚区编码的抗原决定簇。在用A.TH抗A.TL（I-As，I-Ek抗I-Ak，I-Ek）血清包被的I-As、I-Ek细胞的洗脱物中也观察到了相同类型的额外反应。血清和洗脱物中的这种反应性可被解释为I-E和I-A亚区产物之间的交叉反应。

相似文献

1
Serological cross-reactivity between products of separate I regions.不同I区产物之间的血清学交叉反应性。
Immunogenetics. 1982 Jan;15(1):71-7. doi: 10.1007/BF00375504.
2
Monoclonal mouse anti-I-Ak and anti-I-Ek antibodies cross-reacting with HLA-DR supertypic and subtypic determinants rather than classical DR allelic specificities.与HLA - DR超型和亚型决定簇而非经典DR等位基因特异性发生交叉反应的单克隆小鼠抗I - Ak和抗I - Ek抗体。
Tissue Antigens. 1982 Apr;19(4):289-300. doi: 10.1111/j.1399-0039.1982.tb01452.x.
3
Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function.免疫反应基因功能与Ia抗原的表达相关。II. Ae:Eα复合体表达的定量缺陷导致抗原呈递细胞功能出现相应缺陷。
J Exp Med. 1982 Feb 1;155(2):508-23. doi: 10.1084/jem.155.2.508.
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Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements.用抗Ia抗体在体内阻断辅助性T细胞诱导的作用。I-A/E杂交分子作为限制元件的可能作用。
J Exp Med. 1980 Oct 1;152(4):996-1010. doi: 10.1084/jem.152.4.996.
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Molecular specificity of a monoclonal anti-Ik alloantibody identifying a highly conserved determinant on mouse I-A, I-E and human DR antigens.一种单克隆抗-Ik同种抗体的分子特异性，该抗体识别小鼠I-A、I-E和人类DR抗原上的一个高度保守的决定簇。
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Serological cross-reactivity of murine A.TH anti-A.TL antibody (anti-l-Ek antibody) with La-like molecules of human antigen-presenting cells.
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[Serological study of Ia antigens determined at the I-A and I-E sub-regions of the H-E complex in the H-2 complex of mice].[小鼠H-2复合体中H-E复合体I-A和I-E亚区Ia抗原的血清学研究]
C R Seances Acad Sci D. 1980 Jun 2;290(20):1313-6.
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[Ia antigens: markers of specific T suppressors immune to H-2 complex antigens].[Ia抗原：对H-2复合抗原免疫的特异性抑制性T细胞的标志物]
Genetika. 1982 Apr;18(4):639-51.
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Separation of the immune response genes for LDH-B and MOPC-173. II. Description of an immune response defect in B10.ASR7.乳酸脱氢酶B和骨髓瘤蛋白MOPC - 173免疫反应基因的分离。II. B10.ASR7免疫反应缺陷的描述。
J Immunol. 1984 Apr;132(4):1955-9.

引用本文的文献

1
Cytolytic T cells activated by H-2-controlled E molecules cross-react with A molecules.由H-2控制的E分子激活的细胞溶解性T细胞与A分子发生交叉反应。
Immunogenetics. 1982;15(5):519-27. doi: 10.1007/BF00345911.
2
Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules.携带DC1或BR4X7决定簇的人类Ia分子与小鼠I-E分子不同源。
Immunogenetics. 1982;16(3):187-99. doi: 10.1007/BF00343308.
3
Fine specificity of a proliferating T-cell clone activated by a conformational determinant of the I-Ek molecule.

本文引用的文献

1
Detection of CML determinants associated with H-2 controlled E beta and E alpha chains.检测与H-2控制的Eβ和Eα链相关的慢性粒细胞白血病决定簇。
Nature. 1981 Jan 22;289(5795):308-10. doi: 10.1038/289308a0.
2
Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes.不同H-2单倍型小鼠中Eα和Ae（Eβ）Ia多肽链的可变合成与表达
Immunogenetics. 1981;12(3-4):321-37. doi: 10.1007/BF01561674.
3
Analysis of serologic cross-reactions between human and mouse Ia antigens.人和小鼠Ia抗原之间血清学交叉反应的分析。
由I-Ek分子的构象决定簇激活的增殖性T细胞克隆的精细特异性。
Immunogenetics. 1982;15(4):399-412. doi: 10.1007/BF00364263.
J Immunol. 1980 Sep;125(3):1210-5.
4
Serological analysis of a recombination in the H-2 region of the mouse.小鼠H-2区域重组的血清学分析。
Transplantation. 1966 May;4(3):300-22. doi: 10.1097/00007890-196605000-00008.
5
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
6
Structural studies on the murine IA alloantigens. II. Molecular weight characterization of the products of the I-A and I-E/C subregions.小鼠IA同种异体抗原的结构研究。II. I-A和I-E/C亚区产物的分子量特征
J Immunol. 1978 Dec;121(6):2205-12.
7
Trans gene complementation of I-E subregion antigens.
J Immunol. 1979 Sep;123(3):1423-5.
8
Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion.小鼠Ia抗原的结构：I-E或I-C亚区产物的部分NH2末端氨基酸序列。
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5135-9. doi: 10.1073/pnas.74.11.5135.
9
Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.由H-2复合体的i-E/i-C亚区所决定的小鼠Ia同种抗原的化学特性
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5131-4. doi: 10.1073/pnas.74.11.5131.
10
Partial N-terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I-A subregion.对由I-A亚区编码的小鼠Ia分子进行部分N端氨基酸序列分析和比较胰蛋白酶肽图分析。
Eur J Immunol. 1979 Dec;9(12):955-63. doi: 10.1002/eji.1830091209.