Heilmann E, Tillmann P, Lunke G
Schweiz Med Wochenschr. 1975 Dec 20;105(51):1766-7.
In the pathogenesis of anemia in patients on intermittent hemodialysis is a frequently mentioned factor. To evaluate the red blood cell trauma caused by the hemodialyser, free hemoglobin was determined in the plasma before and after various types of hemodialysis. We investigated 22 patients with chronic renal failure in the age range from 18 to 54 years who were hemodialysed with various types of shunt (Cimino, Scribner or Thomas shunt) and hemodialysers (Kiil or Rhone-Poulenc). Determinations of hemoglobin in the plasma before and after 8-h hemodialysis were performed by the method of RICHTERICH. A significant increase in the initial normal values for hemoglobin in the plasma were found, but without any correlation between rate of hemolysis and type of hemodialyser. The presumed mechanical destruction of erythrocytes during hemodialysis can be determined by the free hemoglobin in the plasma. The small extent of intravascular hemolysis does not correlate with the type of hemodialyser.
在接受间歇性血液透析患者的贫血发病机制中，这是一个经常被提及的因素。为评估血液透析器对红细胞造成的损伤，在各类血液透析前后测定血浆中的游离血红蛋白。我们调查了22例年龄在18至54岁之间的慢性肾衰竭患者，他们使用了各类分流术（西米诺分流术、斯克里布纳分流术或托马斯分流术）和血液透析器（基尔血液透析器或罗纳-普朗克血液透析器）进行血液透析。采用里希特里希方法对8小时血液透析前后的血浆血红蛋白进行测定。发现血浆中血红蛋白的初始正常值显著升高，但溶血率与血液透析器类型之间无任何关联。血液透析过程中红细胞假定的机械性破坏可通过血浆中的游离血红蛋白来确定。血管内溶血程度较轻与血液透析器类型无关。
