Boignard A, Fior-Gozlan M, Gressin R, Louis F, Brambilla C, Seigneurin D, Devouassoux G
Unité de Pneumologie, Département de Médecine Aiguë Spécialisée, Hôpital A. Michallon, CHU de Grenoble, Université J. Fourier, Grenoble, France.
Rev Mal Respir. 2002 Jun;19(3):375-7.
The idiopathic hyper-eosinophilic syndrome is defined as a peripheral blood eosinophilia greater than 1.5 x 10(9)/litre present for at least 6 months and associated with visceral involvement. It may only be accepted after carefully excluding the other common or rare causes of hyper-eosinophilia and should remain a diagnosis of exclusion. The associated visceral lesions are multiple and non-specific. Among these neurological, digestive, dermatological and cardiac manifestations are the most frequently described. Whereas pleuro-pulmonary involvement is also common, asthma is rarely reported. We report a case of ideopathic hyper-eosinophilic syndrome presenting as asthma. This was secondary to eosinophilic infiltration of the bronchial mucosa as demonstrated by cytological examination of induced sputum.