Villaseño-García Maria Martha, Puebla-Pérez Ana Maria, Lozoya Xavier
Immunopharmacology of Natural Products Laboratory, Biomedical Research Centre in Western Area, IMSS, Guadalajara, Jalisco, Mexico.
Phytother Res. 2002 May;16(3):253-5. doi: 10.1002/ptr.850.
The phagocytic activity and delayed-type Hypersensitivity (DTH) response to dinitrofluorobenzene (DNFB) of healthy BALB/c mice treated orally (100 mg/kg/day for 7 days) using two Ginkgo biloba extracts were studied. The phytopharmaceuticals Gb 30 (Alban Muller International, France) and EGb 761 (Schwabe, Germany) administered orally stimulated the phagocytic activity of peritoneal and alveolar macrophages. Likewise, the DTH response was found to be increased only with Gb 30 treatment. These results suggest that Ginkgo biloba possesses immunological activity in addition to the biological activity reported. The different chemical concentration of the components of the Ginkgo biloba extracts mentioned above may be responsible for the differences in the observed findings.
研究了使用两种银杏叶提取物经口给药（100毫克/千克/天，持续7天）的健康BALB/c小鼠对二硝基氟苯（DNFB）的吞噬活性和迟发型超敏反应（DTH）。口服给药的植物药Gb 30（法国阿尔班·穆勒国际公司）和Egb 761（德国施瓦贝公司）刺激了腹膜和肺泡巨噬细胞的吞噬活性。同样，仅Gb 30处理可使DTH反应增强。这些结果表明，银杏叶除了具有已报道的生物活性外，还具有免疫活性。上述银杏叶提取物成分的不同化学浓度可能是观察结果差异的原因。
