Puebla-Pérez Ana María, Lozoya Xavier, Villaseñor-García María Martha
Laboratorio de Inmunofarmacología de Productos Naturales, Centro de Investigación Biomédica de Occidente, Mexico.
Int Immunopharmacol. 2003 Jan;3(1):75-80. doi: 10.1016/s1567-5769(02)00215-1.
We evaluated the effects of Ginkgo biloba extract (EGb 761) on the cellular immune response of rats with immunosuppression induced by activation of the hypothalamic-pituitary-adrenal (HPA) axis. Groups of five rats were subjected to chronic stress by the application of daily electric shocks (ES) over 7 days. This stress produced a significant decrement in the delayed-type hypersensitivity response (DTH) to dinitrofluorobenzene (DNFB), and a decrease in the proliferation index of splenocytes. Treatment with oral doses of the phytopharmaceutical EGb 761 (100 mg/kg per day over 7 days) restored both the DTH response to DNFB and the proliferation index. EGb 761 has stress-alleviating properties through its moderation of corticosterone levels. It also possesses antioxidant activity that may contribute to its effects on the immune response. Our observations indicate that the phytopharmaceutical EGb 761 possesses immunostimulatory properties.
我们评估了银杏叶提取物（EGb 761）对下丘脑-垂体-肾上腺（HPA）轴激活诱导的免疫抑制大鼠细胞免疫反应的影响。将每组五只大鼠连续7天每天施加电击（ES）以使其遭受慢性应激。这种应激导致对二硝基氟苯（DNFB）的迟发型超敏反应（DTH）显著降低，以及脾细胞增殖指数下降。口服植物药EGb 761（连续7天每天100 mg/kg）治疗可恢复对DNFB的DTH反应和增殖指数。EGb 761通过调节皮质酮水平具有减轻应激的特性。它还具有抗氧化活性，这可能有助于其对免疫反应的作用。我们的观察结果表明，植物药EGb 761具有免疫刺激特性。
